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Proteins that are low abundant and/or poorly accessible to antibodies can be readily localised with fluorescent streptavidin, when expressed fused to a biotin ligase.

A computational tool developed to construct three-dimensional anatomical atlases from two-dimensional data generates volumetrically complete and aligned atlases for all stages of development in the Allen Developing Mouse Brain Atlas.

Lineage tracing and genetic experiments resolve a long-standing controversy by showing that retinoic acid signaling is active in cardiomyocytes, both during development and after myocardial infarction, and protects damaged hearts from apoptosis.

Epigenetic drift of H3K27me3 is one of the molecular mechanisms that contribute to aging, and stimulation of glycolysis promotes metabolic health and longevity.

A novel mechanism for F-actin repair is involved in the maintenance of sensory hair cells and hearing function.

Uncovering a mechanism for how inflammatory signaling is opposed by a phosphatase identifies a potential druggable target to treat E. coli sepsis.

Vacuolar morphologenesis correlates with cell size and is required for auxin-dependent inhibition of growth.

Isoform-specific transcript localization underlies the evolutionary diversity of anterior axis determinants in embryos of dipteran insects.

Analyses with genetically engineered mouse models in combination with biochemical approaches reveal a crucial role of the receptor tyrosine kinase Tie2 mediated signals in venogenesis via an Akt mediated regulation of COUP-TFII protein stabilization.

Lactate in pancreatic cancer micro-environment can lead to TET enzyme activation and loss of DNA methylation seen in cancer associated fibroblasts.