The cyclic neuropeptide somatostatin binds to human Aβ1-42 through an interface that critically relies on a specific tryptophan, thereby blocking the propensity of Aβ to aggregate, a critical step in the pathobiology of Alzheimer's disease.
The number of different peptides presented by major histocompatibility complex class I molecules to the immune system's T lymphocytes is inversely correlated with cell surface expression and is strongly associated with the response to infectious disease.
In the first study attempting to formally quantify the deleterious impact of research misconduct on funding sources and publication output, we found that misconduct accounts for a small but substantial portion of American biomedical science funding dollars and damages the productivity and rate of funding acquisition of those who commit misconduct.
A more balanced distribution of NIH grant funding among investigators would strengthen the diversity of the research enterprise, increase the likelihood of scientific breakthroughs, and lead to a greater return on taxpayers' investments.
Stochastic tuning of gene expression could be a common mechanism through which eukaryotic cells adapt to challenging external environments, potentially including survival of infectious organisms within the host and adaptation of cancer cells to chemotherapy.