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    1. Computational and Systems Biology
    2. Genetics and Genomics

    Detecting adaptive introgression in human evolution using convolutional neural networks

    Graham Gower, Pablo Iáñez Picazo ... Fernando Racimo
    Convolutional neural networks are an effective tool for detecting archaic adaptive introgression from genomic data.
    1. Genetics and Genomics
    2. Plant Biology

    Epigenetic silencing of a multifunctional plant stress regulator

    Mark Zander, Björn C Willige ... Joseph R Ecker
    Interplay between histone demethylation and chromatin remodeling shapes the chromatin environment of the essential stress regulator ETHYLENE-INSENSITIVE2.
    1. Neuroscience

    Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics

    Yoshinori Aso, Robert P Ray ... Gerald M Rubin
    The interplay of nitric oxide and dopamine specialize one memory unit in a fly brain in predicting the value of odors based only on recent experience.
    1. Cell Biology

    Regulation of cilia abundance in multiciliated cells

    Rashmi Nanjundappa, Dong Kong ... Moe R Mahjoub
    A cell-intrinsic surface area-dependent mechanism establishes centriole-cilia abundance in airway multiciliated cells.
    1. Computational and Systems Biology
    2. Neuroscience

    Biophysical mechanisms in the mammalian respiratory oscillator re-examined with a new data-driven computational model

    Ryan S Phillips, Tibin T John ... Jeffrey C Smith
    Computational modeling motivated by recent experiments clarifies biophysical mechanisms generating the rhythm and amplitude of breathing at the level of neurons and brain circuits in mammals.
    1. Cancer Biology
    2. Evolutionary Biology

    High-density sampling reveals volume growth in human tumours

    Arman Angaji, Michel Owusu ... Johannes Berg
    Spatial genomics reveals the mode of evolution of a tumour based on the positions of mutations in high-resolution samples.
    1. Medicine
    2. Epidemiology and Global Health

    Mapping residual transmission for malaria elimination

    Robert C Reiner Jr, Arnaud Le Menach ... David L Smith
    A fine-grain map of residual transmission and importation in Swaziland shows where to target malaria elimination efforts.
    1. Cell Biology
    2. Neuroscience

    The Na+/K+ pump dominates control of glycolysis in hippocampal dentate granule cells

    Dylan J Meyer, Carlos Manlio Díaz-García ... Gary Yellen
    Neuronal glycolysis to restore energy consumed by ion movements is activated by engagement of the Na+/K+ pump, either directly by Na+ influx or indirectly, when Ca2+ influx is converted to Na+ accumulation by Na+/Ca2+ exchange.
    1. Computational and Systems Biology
    2. Neuroscience

    A functional model of adult dentate gyrus neurogenesis

    Olivia Gozel, Wulfram Gerstner
    The GABA input switching from excitatory to inhibitory during maturation of adult-born dentate granule cells is crucial for their integration into the preexisting circuit.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    How subtle changes in 3D structure can create large changes in transcription

    Jordan Yupeng Xiao, Antonina Hafner, Alistair N Boettiger
    Promoter futile cycles can explain how subtle differences in genome folding sometimes generate large difference in gene expression.