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Analysis of the osteochondral unit of aquatic mammals reveals a distinctly different tissue structure, lacking the arcade-like collagen fiber organization, a calcified cartilage layer and a dense subchondral bone plate, typically seen in osteochondral tissue of terrestrial mammals.

The relationship between APOE genotype and disease risks may be environmentally moderated, with APOE4 being less harmful and unlikely to increase cardiometabolic risk in a physically active, energy-limited population.

The San Francisco Declaration on Research Assessment (DORA) has developed a new tool called SPACE to support universities and institutions working to improve the assessment of research.

Definitions of reproducibility vary considerably across disciplines and overall rates of reproducibility are low irrespective of the definition used.

Preclinical multilaboratory studies are a robust method to assess promising interventions.

The new open-access journal eLife has launched, making its first content available in PubMed Central. In addition to publishing science of the highest quality, the journal aims to improve both the peer-review process and the presentation of new research results.

A text-mining study suggests that about half of the papers reporting the results of experiments on mice do not report the sex and age of the mice.

Non-coding RNAs appear to be good candidates as biomarkers for predicting treatment response and therapeutics for sarcoma, their differential expression across tissues complicates their application.

The best papers provide evidence that can be used to make changes that improve the health and lives of people around the world.

Generative artificial intelligence, such as OpenAI’s ChatGPT, can be used to analyze scientific texts with specialized constructions, including peer review reports.