10,702 results found
    1. Developmental Biology
    2. Evolutionary Biology

    An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice

    João PL Castro et al.
    Genome sequencing of mice selected for longer limbs reveals that rapid selection response is due to both discrete loci and polygenic adaptation.
    1. Genetics and Genomics

    Background selection and biased gene conversion affect more than 95% of the human genome and bias demographic inferences

    Fanny Pouyet et al.
    Background selection and GC-biased gene conversion impact the human genome to a much larger extent than previously recognized in low and high recombination rate regions, respectively.
    1. Ecology

    Sexual selection gradients change over time in a simultaneous hermaphrodite

    Jeroen NA Hoffer et al.
    The quantification of sexual selection reveals that it is important to consider the chosen time frame of measurement as well as the sexual system.
    1. Cancer Biology

    Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

    László Bányai et al.
    In contrast with earlier conclusions, negative selection has a major role in cancer evolution.
    1. Neuroscience

    Neural basis of somatosensory target detection independent of uncertainty, relevance, and reports

    Pia Schröder et al.
    Neural correlates of somatosensory target detection are restricted to secondary somatosensory cortex, whereas activity in insular, cingulate, and motor regions reflects stimulus uncertainty and overt reports.
    1. Computational and Systems Biology
    2. Neuroscience

    Action detection using a neural network elucidates the genetics of mouse grooming behavior

    Brian Q Geuther et al.
    A machine learning method for action detection is developed and applied toward mouse grooming behavior.
    1. Developmental Biology
    2. Immunology and Inflammation

    T cell self-reactivity during thymic development dictates the timing of positive selection

    Lydia K Lutes et al.
    Developing T cells whose TCRs have relatively low reactivity experience very brief TCR signaling events, experience delayed positive selection, and retaina preselection gene expression signature as they mature.
    1. Cell Biology
    2. Immunology and Inflammation

    Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent

    Luise Westernberg et al.
    Antagonistic signaling by the kinases PI3K and Itpkb limits the kinetics and enforces the Notch-dependence of beta-selection – the most important cell-fate determining process in alpha beta T cell development.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    The mobility of packaged phage genome controls ejection dynamics

    Alex Evilevitch
    Temperature and ionic conditions control the mechanical properties of virally encapsidated DNA and act as a switch between synchronized and desynchronized genome ejection dynamics in a phage population.
    1. Computational and Systems Biology

    Selecting the most appropriate time points to profile in high-throughput studies

    Michael Kleyman et al.
    The Time Point Selection (or TPS) method is a general protocol for determining sampling rates for high throughout time series biological studies, that is efficient, cheap, scalable and works well for several different types of molecular data.

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