449 results found
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

    David Trombley McSwiggen, Anders S Hansen ... Xavier Darzacq
    Transient DNA interactions by DNA-binding proteins are utilized by herpes simple virus as an alternative route to generate membraneless compartments in the nucleus without invoking phase separation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

    Eitan Lerner, Anders Barth ... Shimon Weiss
    A summary of the current “state-of-the-field” of single-molecule FRET used for probing biomolecular structural dynamics.
    1. Immunology and Inflammation

    Homeostatic activation of aryl hydrocarbon receptor by dietary ligands dampens cutaneous allergic responses by controlling Langerhans cells migration

    Adeline Cros, Alba De Juan ... Elodie Segura
    Lack of aryl hydrocarbon receptor ligands in the diet of mice increases the inflammatory state in their epidermis, making cutaneous allergic reactions more severe and airway allergy more pronounced after skin sensitization.
    1. Structural Biology and Molecular Biophysics

    Dissecting Mechanisms of Ligand Binding and Conformational Changes in the Glutamine-Binding Protein

    Zhongying Han, Sabrina Panhans ... Thorben Cordes
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Convincing
    1. Neuroscience

    Microprism-based two-photon imaging of the mouse inferior colliculus reveals novel organizational principles of the auditory midbrain

    Baher A Ibrahim, Yoshitaka Shinagawa ... Daniel A Llano
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Cell Biology

    Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity

    Dan Wu, Venkateswararao Eeda ... Weidong Wang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

    Lakshmi E Miller-Vedam, Bastian Bräuning ... Jonathan S Weissman
    Structure-function characterization of the EMC's cytoplasmic, transmembrane, and lumenal domains reveal features critical for terminal helix insertion and a specialized role for the lumenal domain in polytopic membrane protein biogenesis.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Genomic epidemiology of COVID-19 in care homes in the east of England

    William L Hamilton, Gerry Tonkin-Hill ... COVID-19 Genomics Consortium UK
    SARS-CoV-2 can spread efficiently within care homes causing outbreaks among residents, who are at increased risk of severe disease, emphasising the importance of stringent infection control in this population.
    1. Immunology and Inflammation

    S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse

    Amado Carreras-Sureda, Laurence Abrami ... Nicolas Demaurex
    ORAI1 ion channel lipid modification is required for a proper immune synapse formation and T cell activation.
    1. Physics of Living Systems

    Fragmentation and aggregation of cyanobacterial colonies

    Yuri Z Sinzato, Robert Uittenbogaard ... Maziyar Jalaal
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid

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