75 results found
  1. March 2016

    Episode 28: March 2016

    In this episode we hear about aging, artificial fingertips, ancient DNA, antibiotic resistance and dengue fever.
    1. Immunology and Inflammation

    Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells

    Alexandria C Wells et al.
    TCR-mediated downregulation of let-7 microRNAs licenses the differentiation of activated CD8 T cells into cytotoxic T lymphocytes.
    1. Computational and Systems Biology
    2. Developmental Biology

    Elastic force restricts growth of the murine utricle

    Ksenia Gnedeva et al.
    Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.
    1. Neuroscience

    An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans

    Yu Shen et al.
    The activity of a set of GABAergic neurons is causally linked with a locomotory pattern in moving animals, and the mechanisms underlying the neuromodulatory role of GABA are illuminated.
    1. Neuroscience

    A high-throughput neurohistological pipeline for brain-wide mesoscale connectivity mapping of the common marmoset

    Meng Kuan Lin et al.
    A systematic high-throughput neurohistological and computational pipeline for marmoset which establishes a foundational setup in brain mapping and circuit tracing to support current and emerging research in primate studies.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L

    Victoria E Pedanou et al.
    A large-scale RNA interference screen uncovers a new transcriptional regulatory program involving the histone H3 demethylase KDM3A, which mediates detachment-induced apoptosis (anoikis) in breast epithelial cells.
    1. Cell Biology

    Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy

    William A Kronert et al.
    Integrative analysis of a Drosophila model of hypertrophic cardiomyopathy demonstrates that prolonged binding of the myosin cross-bridge to actin is a root cause of the disorder.
    1. Neuroscience

    Mouse rods signal through gap junctions with cones

    Sabrina Asteriti et al.
    Electrophysiological recordings show that cones in the eyes of mice are able to receive strong input from rods via gap junctions, supporting the view that this route plays an important role in vision.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Tuning myosin-driven sorting on cellular actin networks

    Rizal F Hariadi et al.
    Competition between the antagonistic motor proteins myosin V and myosin VI finely tunes unidirectional transport of cargo on different actin architectures.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Nanoresolution real-time 3D orbital tracking for studying mitochondrial trafficking in vertebrate axons in vivo

    Fabian Wehnekamp et al.
    The ability to follow single objects in 3D in a living organism with high spatiotemporal resolution opens new possibilities for quantitative biophysical studies of complex systems in their physiological context.

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