220 results found
    1. Neuroscience

    A resource-rational theory of set size effects in human visual working memory

    Ronald van den Berg, Wei Ji Ma
    Set size effects in visual working memory are explained as a resource-rational trade-off between an error-based behavioral cost and a neural encoding cost.
    1. Evolutionary Biology

    Experimental Evolution: A sticky solution

    David Gresham
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  1. Peer Review: To fund or not to fund?

    Sarah Shailes
    Funding agencies use many different criteria and peer review strategies to assess grant proposals.
  2. Living Science: Power analysis

    Indira M Raman
    After acknowledging that power differentials exist, can scientists find inspiration to persevere anyway?
  3. Research Culture: A survey of new PIs in the UK

    Sophie E Acton et al.
    The challenges faced by new PIs in the UK include difficulties in recruiting PhD students, maintaining a good work-life balance and securing permanent positions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Tandem hnRNP A1 RNA recognition motifs act in concert to repress the splicing of survival motor neuron exon 7

    Irene Beusch et al.
    The structural model of hnRNP A1 shows that it can bind with both RRMs to RNA, which is shown to be relevant for the SMN2 exon 7 splicing mechanism in vivo.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction

    Gurunathan Laxmikanthan et al.
    The structure of a multi-protein DNA recombination reaction intermediate reveals how regulation is achieved by protein-mediated DNA wrapping around a core enzyme-substrate complex.
    1. Cell Biology
    2. Physics of Living Systems

    Morphogenetic degeneracies in the actomyosin cortex

    Sundar Ram Naganathan et al.
    Distinct molecular functions contribute to the same material property at larger scales leading to degenerate functionality.
    1. Computational and Systems Biology

    Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes

    Juliane Liepe et al.
    Experimental and computational analyses reveal how proteasomal hydrolysis is regulated and show that peptide transport is the rate-limiting step and the main differentiating factor between human standard- and immuno-proteasomes.
    1. Structural Biology and Molecular Biophysics

    Architectural principles for Hfq/Crc-mediated regulation of gene expression

    Xue Yuan Pei et al.
    Structural insights show how RNA chaperones cooperate to recognise defined target transcripts and suppress gene expression.

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