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    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Molecular dynamics-based refinement and validation for sub-5 Å cryo-electron microscopy maps

    Abhishek Singharoy, Ivan Teo ... Klaus Schulten
    New hybrid structure determination methods leveraging the inherent biophysical properties of a macromolecule through molecular dynamics simulations provide accurate and cost-efficient ways of achieving atomic structures from high resolution cryo-electron density maps.
    1. Neuroscience

    Hippocampal neurogenesis enhancers promote forgetting of remote fear memory after hippocampal reactivation by retrieval

    Rie Ishikawa, Hotaka Fukushima ... Satoshi Kida
    Forgetting of remote fear memory is promoted by increased hippocampal neurogenesis only after hippocampal reactivation by long time memory retrieval.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Satb2 determines miRNA expression and long-term memory in the adult central nervous system

    Clemens Jaitner, Chethan Reddy ... Galina Apostolova
    The genome-organizer Satb2 has a key role in memory formation by modulating availability of miRNAs that control the function of synapses.
    1. Neuroscience

    Neural pattern change during encoding of a narrative predicts retrospective duration estimates

    Olga Lositsky, Janice Chen ... Kenneth A Norman
    Judgments of how much time elapsed between two events in a story are predicted by changes in fMRI activity patterns.
    1. Cancer Biology
    2. Computational and Systems Biology

    Mitochondrial respiratory gene expression is suppressed in many cancers

    Ed Reznik, Qingguo Wang ... Chris Sander
    Building on previous work (Reznik et al., 2016), independent measurements of mitochondrial genome copy number and expression indicate that several solid tumor types suppress respiratory metabolism compared to normal tissue.
    1. Microbiology and Infectious Disease

    Biofilms: Take my breath away

    Vinai C Thomas, Paul D Fey
    A lack of oxygen activates a pathway that causes the bacterial cell wall to break down, which, in turn, aids bacterial biofilm development.
    Version of Record
    Insight
    1. Microbiology and Infectious Disease

    Impaired respiration elicits SrrAB-dependent programmed cell lysis and biofilm formation in Staphylococcus aureus

    Ameya A Mashruwala, Adriana van de Guchte, Jeffrey M Boyd
    The absence of oxygen prompts Staphylococcus aureus cells to rupture resulting in increased formation of biofilms, which are the etiological agents of recurrent infections.
    1. Cancer Biology
    2. Developmental Biology

    A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)

    Imelda T Sandoval, Richard Glenn C Delacruz ... David A Jones
    The tumor suppressor APC regulates a metabolic program that drives normal intestinal differentiation in zebrafish.
    1. Neuroscience

    Dynamic modulation of decision biases by brainstem arousal systems

    Jan Willem de Gee, Olympia Colizoli ... Tobias H Donner
    Rapid increases in the brain’s level of alertness, or arousal, contribute to variability in decision making by reducing existing biases.
    1. Immunology and Inflammation

    Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

    Michael Saitakis, Stéphanie Dogniaux ... Claire Hivroz
    Multiple functions of human T lymphocytes are shown to be potentiated within a wide range of physiological cell and tissue rigidities.