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    1. Cell Biology

    Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

    Zewei Zhao, Longyun Hu ... Zhonghan Yang
    ADGRA3 signaling promotes adipose thermogenesis via Gs-PKA-CREB, suggesting hesperetin and ADGRA3 overexpression as obesity therapies.
    1. Neuroscience

    Opioid analgesia alters corticospinal coupling along the descending pain system in healthy participants

    Alexandra Tinnermann, Christian Sprenger, Christian Büchel
    Corticospinal functional MRI reveals that the opioid remifentanil and the level of perceived analgesia modulate coupling strength between the prefrontal cortex, brainstem, and spinal cord.
    1. Neuroscience

    The influence of the descending pain modulatory system on infant pain-related brain activity

    Sezgi Goksan, Luke Baxter ... Rebeccah Slater
    Greater connectivity of the descending pain modulatory system network in the infant brain is associated with lower pain-related brain activity.
    1. Cancer Biology

    Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

    Zeyad D Nassar, Chui Yan Mah ... Lisa M Butler
    DECR1, a rate-limiting enzyme for polyunsaturated fatty acid (PUFA) β-oxidation, is an androgen-repressed gene in prostate cancer cells that limits oxidative stress to promote cancer cell survival.
    1. Developmental Biology
    2. Neuroscience

    Chronology-based architecture of descending circuits that underlie the development of locomotor repertoire after birth

    Avinash Pujala, Minoru Koyama
    Newly forming descending pathways are arranged to function in parallel to existing ones and contribute to increasingly sophisticated locomotor behaviors that emerge postnatally with suitable connectivity patterns and biophysical properties.
    1. Cancer Biology

    Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

    Volkan I Sayin, Sarah E LeBoeuf ... Thales Papagiannakopoulos
    Activation of the NRF2 antioxidant program leads to an imbalance in central carbon metabolism and sensitizes cancers to glutaminase inhibition.
    1. Developmental Biology

    Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis

    Haruko Nakano, Itsunari Minami ... Atsushi Nakano
    During cardiogenesis, the major role of glucose is not the catabolic extraction of energy but the anabolic biosynthesis of nucleotides.
    1. Neuroscience

    Drp1 is required for AgRP neuronal activity and feeding

    Sungho Jin, Nal Ae Yoon ... Sabrina Diano
    Mitochondrial fission, associated with fatty acids oxidation, is fundamental for AgRP neuronal activity during negative energy balance and in regulating fasting- and/or ghrelin-induced feeding.
    1. Medicine
    2. Neuroscience

    Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor

    Katrin H Preller, Joshua B Burt ... Alan Anticevic
    LSD induces a pattern of changed global brain connectivity characterized by hypo-connectivity in associative areas and hyper-connectivity across sensory and somatomotor areas that is dependent on the serotonin 2A receptor.
    1. Neuroscience

    Unravelling the neurocognitive mechanisms underlying counterconditioning in humans

    Lisa Wirz, Maxime C Houtekamer ... Erno J Hermans
    Not revised
    Reviewed Preprint v1
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