Patients exposed to ⍺1-AR antagonists have reduced risks of mechanical ventilation and death in lower respiratory tract infection-related illnesses, highlighting the need for prospective trials assessing ⍺1-AR antagonists' effectiveness in COVID-19.
Interferon-λ plays a decisive and previously underestimated role in limiting the spread of respiratory viruses from the nasal cavity to the lungs and it efficiently restricts virus transmission from infected individuals to naïve contacts.
A respiratory tissue-associated commensal Lactobacillus strain confers colonization resistance to Streptococcus pneumoniae, when applied therapeutically in a post influenza virus super-infection model.
Broader case variation in respiratory viral load, and in shedding virus via droplets and aerosols, for SARS-CoV-2 than influenza A(H1N1)pdm09 facilitates greater transmission heterogeneity in the COVID-19 pandemic than the 2009 flu pandemic.
A meta-analysis shows that seroconversion of antibodies against SARS-CoV-2 is not affected by disease severity and finds higher viral RNA detection probability in lower respiratory tract and fecal samples.
Pet1 neurons actively maintain cardiorespiratory tone and dynamic range in mouse neonates and critically support the recovery response to apneas, informing brain findings in the sudden infant death syndrome.