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    1. Neuroscience

    Acute perturbation of Pet1-neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery

    Ryan T Dosumu-Johnson, Andrea E Cocoran ... Susan M Dymecki
    Pet1 neurons actively maintain cardiorespiratory tone and dynamic range in mouse neonates and critically support the recovery response to apneas, informing brain findings in the sudden infant death syndrome.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Mitochondrial volume fraction and translation duration impact mitochondrial mRNA localization and protein synthesis

    Tatsuhisa Tsuboi, Matheus P Viana ... Brian M Zid
    Mitochondria can tune the protein synthesis of nuclear-encoded proteins through condition-dependent mRNA localization that is regulated by translation elongation and the geometric constraints of the cell.
    1. Microbiology and Infectious Disease

    Respiratory and intestinal epithelial cells exhibit differential susceptibility and innate immune responses to contemporary EV-D68 isolates

    Megan Culler Freeman, Alexandra I Wells ... Carolyn B Coyne
    Parallel studies in primary human airway cells and stem cell-derived enteroids show that Enterovirus D-68 differentially infects and induces innate immune signaling in the respiratory and intestinal epithelium.
    1. Genetics and Genomics

    Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function

    William R Reay, Sahar I El Shair ... Murray J Cairns
    Genetic data revealed existing drugs that could be repurposed to improve lung function, with evidence that compounds which control blood glucose could be particularly useful for respiratory impairment.
    1. Neuroscience

    Ingestible pills reveal gastric correlates of emotions

    Giuseppina Porciello, Alessandro Monti ... Salvatore Maria Aglioti
    Direct measures of inner gastrointestinal signals via ingestible capsules highlight the role of stomach pH in shaping human feelings of disgust, fear and happiness.
    1. Epidemiology and Global Health

    Quantifying antibody kinetics and RNA detection during early-phase SARS-CoV-2 infection by time since symptom onset

    Benny Borremans, Amandine Gamble ... James O Lloyd-Smith
    A meta-analysis shows that seroconversion of antibodies against SARS-CoV-2 is not affected by disease severity and finds higher viral RNA detection probability in lower respiratory tract and fecal samples.
    1. Epidemiology and Global Health

    Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS-CoV-2 receptor

    Hui Liu, Junyi Xin ... Xia Jiang
    Smoking, measured by both initiation and intensity, are significantly associated with an elevated expression level of ACE2 in multiple human tissues/organs, subsequently increasing the susceptibility and severity of COVID-19.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Extracellular electron transfer increases fermentation in lactic acid bacteria via a hybrid metabolism

    Sara Tejedor-Sanz, Eric T Stevens ... Maria L Marco
    Lactic acid bacteria engage a hybrid metabolism which blends features of fermentation and respiration when they perform extracellular electron transfer.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

    Yiska Weisblum, Fabian Schmidt ... Paul D Bieniasz
    SARS-CoV-2 spike variants that resist neutralization by therapeutic antibodies or convalescent plasma can be generated in the laboratory and exist at low frequency in natural populations.
    1. Developmental Biology

    Chloride channels regulate differentiation and barrier functions of the mammalian airway

    Mu He, Bing Wu ... Lily Yeh Jan
    The chloride channel Ano1/Tmem16a plays an essential and non-redundant role in the developing airway by inhibiting mucus cell hyperplasia and promoting proper immune function of the airway mucosal barrier.