The cryo-EM structure of a functional human NOX2-p22 complex in nanodisc in the resting state reveals the architecture of this key enzyme essential for innate immunity.

The structure of the entire Mot1 Swi2/Snf2 protein uncovers an unexpected auto-inhibited resting state activated by substrate binding, and suggests a DNA pulling mechanism of TBP displacement.

The amino terminus of acid-sensing ion channel 1a forms a reentrant 'loop' that frames the lower pore and harbors a conserved 'His-Gly' motif implicated in gating and ion selectivity mechanisms.

Head-to-head interactions of regulatory coiled-coil domains control activity of the central bacterial AAA+ protein ClpC by promoting formation of a reversible resting state.

L-amino acids are agonists of calcium-sensing receptor, and act jointly with calcium and phosphate ions to control receptor function.

Molecular structure of mitochondrial complex I from Drosophila melanogaster reveals a structural element not seen in other organisms to date that may regulate the transition between an off-pathway resting state and the active state of the complex.

Structure modeling, site-directed mutagenesis, and current recordings revealed the mechanism by which stabilization of voltage sensors in the resting and activated states determines the gating properties of the Ca_V1.1 calcium channel.

Human fMRI experiments reveal differences in the propagation of spontaneous brain activity during sleep versus wakefulness.

Connectivity fingerprint matching bridges the gap between mouse and primate neuroanatomy, addressing crucial questions surrounding brain evolution that likely impact translation across species.

The strongest peak frequency of brain oscillations in a brain area decreases significantly, gradually and robustly along the posterior-anterior axis following the global hierarchy from early sensory to higher order areas.