3,690 results found
    1. Cell Biology

    Glucose restriction drives spatial reorganization of mevalonate metabolism

    Sean Rogers et al.
    Genetic and biochemical analyses, coupled with fluorescence imaging, reveal that spatial compartmentalization of HMG-CoA Reductases at yeast ER-lysosome contacts modulates mevalonate pathway flux during glucose restriction, enabling metabolic adaptation.
    1. Neuroscience

    Network dynamics underlying OFF responses in the auditory cortex

    Giulio Bondanelli et al.
    Computational modeling demonstrates that population dynamics of neural calcium activity following stimulus offset are consistent with a network mechanism based on recurrent interactions.
    1. Developmental Biology

    Paternal multigenerational exposure to an obesogenic diet drives epigenetic predisposition to metabolic diseases in mice

    Georges Raad et al.
    Predisposition to obesity-associated diseases is dependent on the ancestors' diet.
    1. Evolutionary Biology

    Striking parallels between dorsoventral patterning in Drosophila and Gryllus reveal a complex evolutionary history behind a model gene regulatory network

    Matthias Pechmann et al.
    Crucial functions of Toll signalling during dorsoventral axis formation might have evolved convergently in flies and crickets.
    1. Neuroscience

    Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex

    Shinya Ohara et al.
    The connection from layer Vb-to-Va neurons, a key component of the canonical hippocampal-cortical output circuit, which is allegedly crucial for memory consolidation, is relatively stronger in lateral entorhinal cortex compared with the medial entorhinal cortex, thus suggesting different operating principles.
    1. Neuroscience

    Slowing the body slows down time perception

    Rose De Kock et al.
    The perception of time is influenced by movement environments, with slower movements associated with shorter perceived time intervals.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation

    Emma Carley et al.
    Forces stemming from cell-matrix adhesions, but not cell-cell adhesions, are directly transmitted to the nuclear lamina to regulate epidermal cell fate.
    1. Neuroscience

    A visual pathway for skylight polarization processing in Drosophila

    Ben J Hardcastle et al.
    Circuit tracing and in vivo calcium imaging reveals neurons conveying polarized light information from photoreceptors to the central brain, transforming patterns in the sky into a directional cue for navigation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Generic injuries are sufficient to induce ectopic Wnt organizers in Hydra

    Jack F Cazet et al.
    Injuries activate the oral identity-specifying canonical Wnt signaling pathway in Hydra, which can trigger head regeneration in permissive tissue contexts created by the absence of pre-existing organizers.

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