Definition of leukemia gene expression mechanisms reveals general principles of cancer gene control and offers a pharmacologic strategy for its therapeutic reprogramming.
The primary respiratory defect seen in aged cardiomyocytes is an elevated proton leak mediated by ANT1, and this is prevented by treatment with SS-31 (elamipretide).
The INM protein LAP1B, an activator of Torsin ATPases, is a chromatin-binding factor that erroneously persists on mitotic chromatin if Torsin functionality is compromised, inducing chromosome segregation defects and binucleation.
A disinhibitory motif in the retina mediates noise resilience of motion detection using an inverted algorithm of disinhibition due to the interplay between network activity and synaptic plasticity.
Primary cilia on endothelial cells are required for VEGF-A/ VEGFR2-dependent signaling, islet vascularization and, consequently, nutrient delivery and insulin disposal.
Silencing of stem cell identity genes during progenitor commitment ensures that intermediate progenitors robustly commit to generate differentiated cell types rather than abnormal stem-cell-like cells during indirect neurogenesis.
