3,721 results found
    1. Developmental Biology
    2. Neuroscience

    Achieving functional neuronal dendrite structure through sequential stochastic growth and retraction

    André Ferreira Castro et al.
    An optimal wire and function trade-off emerges from noisy growth and stochastic retraction during Drosophila class I ventral posterior dendritic arborisation (c1vpda) dendrite development.
    1. Chromosomes and Gene Expression

    Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice

    Liou Y Sun et al.
    Mice with a mutation that disrupts the release of growth hormone show greatly increased lifespan, which can be further increased by caloric restriction.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races

    Jeannette L Tenthorey et al.
    Mutations in the TRIM5α retrovirus-binding interface frequently improve but rarely disrupt retroviral restriction.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages

    Jay Lubow et al.
    Interactions between HIV-1 Env and human mannose receptor enhance HIV entry but restrict viral egress and spread in the absence of Vpr.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α

    Jonathan M Wagner et al.
    Higher-order assembly enables and links pathogen recognition and downstream steps in the TRIM5-mediated anti-HIV response.
    1. Chromosomes and Gene Expression

    miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila

    Manish Pandey et al.
    miR-125 functions as a potential dietary restriction mimetic by promoting longevity through regulation of fat metabolism.
    1. Evolutionary Biology
    2. Medicine

    A dietary sterol trade-off determines lifespan responses to dietary restriction in Drosophila melanogaster females

    Brooke Zanco et al.
    Micronutrients, not macronutrients, regulate lifespan.
    1. Cell Biology

    A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction

    Mira I Pronobis et al.
    A new dynamic mechanistic model explains how the destruction complex negatively regulates Wnt signaling in development and oncogenesis.
    1. Developmental Biology
    2. Immunology and Inflammation

    Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction

    Jennifer C Regan et al.
    In the fruit fly Drosophila melanogaster, stem cell activity ages female guts but not male guts; furthermore, males with feminized guts develop pathologies but gain an increase in lifespan through dietary restriction.
    1. Cell Biology
    2. Developmental Biology

    Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues

    Katarzyna Nowak et al.
    Nutrient limitation elicits differential responses in cells lacking the tumor suppressor PTEN and in normal cells, resulting in hyperplastic overgrowth of PTEN mutant tissue independent of additional mutations.

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