2,324 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α

    Jonathan M Wagner et al.
    Higher-order assembly enables and links pathogen recognition and downstream steps in the TRIM5-mediated anti-HIV response.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

    Ruben Soto-Acosta et al.
    The Zika virus subgenomic flaviviral RNA binds to and inhibits the fragile X mental retardation protein, a novel Zika virus restriction factor.
    1. Microbiology and Infectious Disease

    A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV

    Molly OhAinle et al.
    Host restriction factors that block cross-species transmission also play a role in limiting the replication of highly-adapted HIV-1 in IFN-stimulated cells.
    1. Cell Biology
    2. Neuroscience

    The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes

    Shawn McClelland et al.
    Uncovering the mechanisms by which the transcription factor NRSF contributes to the development of epilepsy reveals that the regulation of gene expression by transcription factors in the brain is more finely-tuned than previously thought.
    1. Chromosomes and Gene Expression

    The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

    Yuan Zhang et al.
    Transgenic mice with high levels of FGF21 live for longer than wild-type mice and do so without reducing food intake.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids

    Yen-Li Li et al.
    To protect mammals against retroviral infections, TRIM5 restriction factors recognize viral capsids by forming complementary hexagonal nets that can adapt to the patterns of capsid protein subunits on the viral capsid surface.
  1. Careers: eLife and early career researchers

    Randy Schekman et al.
    There are many reasons for submitting your best work to eLife, especially if you are an early career researcher.
    Editorial
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