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To protect mammals against retroviral infections, TRIM5 restriction factors recognize viral capsids by forming complementary hexagonal nets that can adapt to the patterns of capsid protein subunits on the viral capsid surface.

The sialylation of RANK⁺TLR2⁺ monocytes contributes to osteoclastogenesis and bone destruction in rheumatoid arthritis.

Investigation of mouse models from forward mutagenetic screen reveals that the gene Spag7 is essential for embryonic development and energy homeostasis later in life.

Transcriptomic and genetic analyses of FoxO target genes reveal a key function of ER-associated protein degradation in growth regulation of Tsc1-deficient tissues.

Interactions between HIV-1 Env and human mannose receptor enhance HIV entry but restrict viral egress and spread in the absence of Vpr.

Expression of Bisphosphoglycerate mutase, a key enzyme affecting the release of oxygen from hemoglobin, is augmented in the murine placenta challenged by gestational hypoxia in mice while its expression is attenuated in placenta of human FGR.

miR-125 functions as a potential dietary restriction mimetic by promoting longevity through regulation of fat metabolism.

A new dynamic mechanistic model explains how the destruction complex negatively regulates Wnt signaling in development and oncogenesis.

In the fruit fly Drosophila melanogaster, stem cell activity ages female guts but not male guts; furthermore, males with feminized guts develop pathologies but gain an increase in lifespan through dietary restriction.

Uracil/adenine base pairs in HIV-1 DNA are attacked by the uracil base excision repair machinery in macrophages, which leads to HIV restriction and viral genome diversification by transcription-associated mutagenesis.