Topoisomerase IV and the ter-binding protein MatP competitively bind the hinge domain of the Escherichia coli Structural Maintenance of Chromosomes complex, MukB, leading to spatiotemporal regulation of MukBEF-topoisomerase IV activity.
Myogenin promotes centrosome attenuation and establishes the nuclear envelope as the dominant microtubule organization center via the scaffold protein AKAP6, which is required for the recruitment of centrosomal proteins.
Biological- or artificial-arm experience during early development has a significant effect on artificial-arm motor control in adulthood, providing evidence for limited sensorimotor plasticity beyond childhood.
The RNA-mediated higher order assembly of TDP-43, a protein associated with neurodegenerative diseases, preserves its solubility by reducing the risk of multivalent interactions between low complexity domains.
A combination of spatial proteomic and autophagic flux approaches was used to reveal the landscape of turnover of damaged lysosomes, demonstrating a key role for the autophagy receptor TAX1BP1 and its associated kinase TBK1 in both HeLa cells and iNeurons.