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Page 2 of 374
Edited by Eve Marder
Essays on the human side of science by Eve Marder.
Episode 7: December 2013
In this episode we hear about drug resistance, severe brain damage, sugar versus sweetener, public goods dilemmas, and the evolution of the machinary that makes proteins in cells.
Episode 31: August 2016
In this episode we hear about human height, fish joints, colour vision, chimpanzees using tools and open science.
Episode 3: August 2013
In this episode we hear about the cocktail party effect, the role of psuedogene RNA in the immune response, the genetic origins of a common form of blindness, the flu vaccine, and the origins of schistosomiasis.
Stem Cells and Regenerative Medicine
Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons
Joseph Herdy et al.
An unbiased RNAseq based strategy to identify targetable pathways and a streamlined lentiviral system provide a state of the art advance on direct fibroblast to neuron conversion.
Genetics and Genomics
The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs
Axelle Marchant et al.
Regulatory evolution allows paralogs to escape from strucural pleiotropy.
Structural Biology and Molecular Biophysics
Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity
Wenlei Ye et al.
TMEM16F shifts its ion selectivity in response to change of intracellular Ca
, membrane potential and ionic strength.
Genetics and Genomics
Ancient origins of arthropod moulting pathway components
André Luiz de Oliveira et al.
Evolutionary reconstruction of the ecdysis pathway shows that its major elements are present in the majority of metazoans, providing evidence that they originated much earlier than currently assumed.
Microbiology and Infectious Disease
cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions
Elizabeth A Mueller et al.
Environmental specialization of bacterial cell wall synthases influences intrinsic resistance to cell wall active antibiotics.
Immunology and Inflammation
The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets
Takuya Koike et al.
Unveiling a mechanism for the fate decision of B-cell differentiation into two functionally distinct memory B cell subsets.
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