Unique 'true' S-cone and S-cone bipolar cell distribution patterns in the mouse retina are previously unappreciated anatomical features that support enhanced short-wavelength signaling for color detection above horizon.
3D niche topology imposes a spatially biased random stem cell loss, which is differentially fine-tuned in neural retina and retinal pigmented epithelium to regulate growth, shape, and cellular topology.
Establishing retinal contrast transmission as a novel determinant of mammalian fitness, this research adds functional significance to a prominent exception of nuclear organization, previously described in nocturnal rod photoreceptor cells.
The direction-selective circuit in the retina adjusts the contributions of excitatory and inhibitory mechanisms under different stimulus conditions to generate context-dependent neural representations of visual features.
While photoreceptor and bipolar cells exhibit very similar cis-regulatory grammars, subtle differences in homeodomain motif enrichment represent a key distinction driving the divergence in their transcriptomes.