130 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers

    Chris Cho et al.
    Discs large homologue 1 (Dlg1) activates beta-catenin (i.e., canonical Wnt) signaling in CNS endothelial cells to regulate retinal angiogenesis and the development and maintenance of the blood-brain and blood-retina barriers.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

    Shogo Sawaguchi et al.
    The transfer of O-GlcNAc by EOGT to specific EGF repeats of NOTCH1 promotes DLL4 binding, Notch signaling, and retinal vascular development.
    1. Cell Biology
    2. Developmental Biology

    Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy

    Claudia Prahst et al.
    Improved 3D and 4D imaging of neurovascular processes across scales reveals new insights into eye disease mouse models and shows retinal vessels are significantly distorted using standard flat-mount confocal imaging.
    1. Stem Cells and Regenerative Medicine

    Role of IL-4 in bone marrow driven dysregulated angiogenesis and age-related macular degeneration

    Takashi Baba et al.
    The IL-4/IL-4Rα axis directory promotes pathological angiogenesis through communications with bone marrow cells leading to neovascular age-related macular degeneration.
    1. Cell Biology
    2. Developmental Biology

    CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity

    Myo-Hyeon Park et al.
    Cyr61 autoregulating tip cell activity by interlinking integrin and Hippo pathway and targeting Cyr61 provides promising therapeutic approach for the treatment of pathological angiogenesis, including tumour angiogenesis.
    1. Cell Biology
    2. Computational and Systems Biology

    A regulatory microRNA network controls endothelial cell phenotypic switch during sprouting angiogenesis

    Stefania Rosano et al.
    Coordinated microRNAs activity induced by VEGF represses cell proliferation and favors cell migration at the onset of sprouting angiogenesis in endothelial cells.
    1. Cell Biology

    Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin

    Ross O Smith et al.
    Pathological vessel leakage in mouse retinopathy models depends on VE-cadherin Y685 phosphorylation status, which in turn is regulated by a signaling cascade originating with VEGFR2 Y949 phosphorylation.
    1. Computational and Systems Biology
    2. Developmental Biology

    Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion

    Benedetta Ubezio et al.
    Increasing levels of the growth factor Vegfa disrupt blood vessel branching morphogenesis and drive diameter increase by synchronizing Notch signalling fluctuations between endothelial cells.
    1. Developmental Biology

    Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII

    Man Chu et al.
    Analyses with genetically engineered mouse models in combination with biochemical approaches reveal a crucial role of the receptor tyrosine kinase Tie2 mediated signals in venogenesis via an Akt mediated regulation of COUP-TFII protein stabilization.
    1. Developmental Biology

    Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding

    Maria V Gelfand et al.
    Interactions between Neuropilin-1 and VEGFR2, rather than VEGF-Neuropilin-1 binding, underlie Neuropilin-1's critical function in VEGF-mediated vascular development.

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