Tumoral group phenotypic compositions and their relationships with the fitness of individual malignant cells in different ecological contexts represent crucial, previously unexplored dynamics in tumor progression.

COVID-19 survivors, who are at risk for vascular complications, would benefit from close monitoring and preventive therapy.

Malaria remodels the spleen to imprint tolerance and reduce pathology in subsequent infections.

Mid-gestational exposure to maternal immune activation drives a sequence of transcriptional signatures and developmental pathology in embryonic mouse cortex, culminating in altered lamination and cellular lineage specification.

SWELL1 is required for basal, stretch, and flow-mediated endothelial AKT-eNOS signaling in vitro and protects against angiotensin-induced hypertension and diabetes-associated vascular dysfunction in vivo.

In contrast with earlier conclusions, negative selection has a major role in cancer evolution.

Deep and comprehensive proteomic resource of human intervertebral disc at high spatial resolution with a methodological flow reveals new insights in disc homeostasis and degeneration.

Characterization of the effects of complement- and inflammasome-mediated inflammation on choroidal neovascularization in a mouse model of neovascular age-related macular degeneration suggests synergistic benefits from targeting both forms of inflammation.

The hepatic endocannabinoid/CB₁R system controls the soluble leptin receptor’s expression and/or subsequent release by Trib3-induced regulation of C/EBP homologous protein levels in hepatocytes to affect leptin signaling in the liver.

Analysis of proteomic data identified protein biomarkers of aging, mortality and aging-related diseases, supporting their use to monitor aging trajectories and identify individuals at higher risk of disease.