111 results found
    1. Evolutionary Biology

    Group phenotypic composition in cancer

    Jean-Pascal Capp et al.
    Tumoral group phenotypic compositions and their relationships with the fitness of individual malignant cells in different ecological contexts represent crucial, previously unexplored dynamics in tumor progression.
    1. Cell Biology
    2. Immunology and Inflammation

    Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

    Florence WJ Chioh et al.
    COVID-19 survivors, who are at risk for vascular complications, would benefit from close monitoring and preventive therapy.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria

    Wiebke Nahrendorf et al.
    Malaria remodels the spleen to imprint tolerance and reduce pathology in subsequent infections.
    1. Genetics and Genomics
    2. Neuroscience

    Sequential perturbations to mouse corticogenesis following in utero maternal immune activation

    Cesar P Canales et al.
    Mid-gestational exposure to maternal immune activation drives a sequence of transcriptional signatures and developmental pathology in embryonic mouse cortex, culminating in altered lamination and cellular lineage specification.
    1. Cell Biology

    The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function

    Ahmad F Alghanem et al.
    SWELL1 is required for basal, stretch, and flow-mediated endothelial AKT-eNOS signaling in vitro and protects against angiotensin-induced hypertension and diabetes-associated vascular dysfunction in vivo.
    1. Cancer Biology

    Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

    László Bányai et al.
    In contrast with earlier conclusions, negative selection has a major role in cancer evolution.
    1. Computational and Systems Biology

    DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics

    Vivian Tam et al.
    Deep and comprehensive proteomic resource of human intervertebral disc at high spatial resolution with a methodological flow reveals new insights in disc homeostasis and degeneration.
    1. Immunology and Inflammation

    Distinct effects of complement and of NLRP3- and non-NLRP3 inflammasomes for choroidal neovascularization

    Jakob Malsy et al.
    Characterization of the effects of complement- and inflammasome-mediated inflammation on choroidal neovascularization in a mouse model of neovascular age-related macular degeneration suggests synergistic benefits from targeting both forms of inflammation.
    1. Cell Biology

    CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance

    Adi Drori et al.
    The hepatic endocannabinoid/CB1R system controls the soluble leptin receptor’s expression and/or subsequent release by Trib3-induced regulation of C/EBP homologous protein levels in hepatocytes to affect leptin signaling in the liver.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Plasma proteomic biomarker signature of age predicts health and life span

    Toshiko Tanaka et al.
    Analysis of proteomic data identified protein biomarkers of aging, mortality and aging-related diseases, supporting their use to monitor aging trajectories and identify individuals at higher risk of disease.

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