366 results found
    1. Neuroscience

    TRPV4 overactivation enhances cellular contractility and drives ocular hypertension in TGFβ2 overexpressing eyes

    Christopher N Rudzitis, Monika Lakk ... David Križaj
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Cell Biology
    2. Computational and Systems Biology

    Unbiased identification of cell identity in dense mixed neural cultures

    Sarah De Beuckeleer, Tim Van De Looverbosch ... Winnok H De Vos
    Morphological profiling allows accurate identification of cell types in dense iPSC-derived cultures, allowing its use for quality control and differentiation monitoring.
    1. Neuroscience

    Encoding of cerebellar dentate neuron activity during visual attention in rhesus macaques

    Nico A Flierman, Sue Ann Koay ... Chris I De Zeeuw
    Dentate nucleus neurons can dynamically modulate their activity during a visual attention task, comprising not only sensorimotor but also cognitive attentional components.
    1. Neuroscience

    Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    François Kroll, Joshua Donnelly ... Jason Rihel
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

    Elise S Bruguera, Jacob P Mahoney, William I Weis
    Biophysical binding and structural prediction studies reveal that Tetraspanin12 directly binds the ligand Norrin, in a manner that is negatively cooperative with Norrin-Fzd4 binding and competitive with Norrin-LRP5/6 binding.
    1. Immunology and Inflammation

    Downregulation of semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis

    Miki Kume, Hanako Koguchi-Yoshioka ... Rei Watanabe
    Downregulation of Sema4A in keratinocytes induces psoriatic non-lesional features, with its signaling cascades potentially triggering psoriasis and serving as targets for treatment and prevention.
    1. Neuroscience

    The emergence of visual category representations in infants’ brains

    Xiaoqian Yan, Sarah Shi Tung ... Kalanit Grill-Spector
    Scalp electroencephalography combined with a frequency tagging method reveals that distinct responses to daily categories emerge at different ages in infants.
    1. Developmental Biology

    Basement membranes are crucial for proper olfactory placode shape, position and boundary with the brain, and for olfactory axon development

    Pénélope Tignard, Karen Pottin ... Marie Anne Breau
    Laminin gamma1-dependent basement membranes are required for multiple aspects of olfactory system development in zebrafish, including the maintenance of placode tissue shape and the growth of the olfactory axons.
    1. Neuroscience

    A neuronal least-action principle for real-time learning in cortical circuits

    Walter Senn, Dominik Dold ... Mihai A Petrovici
    A principle from which the neuronal dynamics and synaptic plasticity in arbitrary network architectures can be inferred, so that output errors are online minimized while simultaneously processing sensory input streams.
    1. Cell Biology

    Defective Neurogenesis in Lowe Syndrome is Caused by Mitochondria Loss and Cilia-related Sonic Hedgehog Defects

    Chien-Hui Lo, Siyu Chen ... Yang Sun
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete

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