366 results found
    1. Neuroscience

    A neuronal least-action principle for real-time learning in cortical circuits

    Walter Senn, Dominik Dold ... Mihai A Petrovici
    A principle from which the neuronal dynamics and synaptic plasticity in arbitrary network architectures can be inferred, so that output errors are online minimized while simultaneously processing sensory input streams.
    1. Developmental Biology
    2. Neuroscience

    Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

    Subhash Kulkarni, Monalee Saha ... Pankaj Jay Pasricha
    Mesoderm-derived enteric neurons born in the post-natal vertebrates drive maturation and aging of the enteric nervous system.
    1. Neuroscience

    The emergence of visual category representations in infants’ brains

    Xiaoqian Yan, Sarah Shi Tung ... Kalanit Grill-Spector
    Scalp electroencephalography combined with a frequency tagging method reveals that distinct responses to daily categories emerge at different ages in infants.
    1. Neuroscience

    Experimentally induced active and quiet sleep engage non-overlapping transcriptional programs in Drosophila

    Niki Anthoney, Lucy Tainton-Heap ... Bruno van Swinderen
    Different methods for inducing sleep in Drosophila flies may be promoting distinct sleep stages with different functions when brain activity and gene expression are compared.
    1. Neuroscience
    2. Physics of Living Systems

    A theory of synaptic transmission

    Bin Wang, Olga K Dudko
    The analytic theory establishes the general principles of synaptic transmission, enables extraction of microscopic parameters of synaptic fusion machinery from experiments, and links molecular constituents to synaptic function.
    1. Neuroscience

    Motor context dominates output from purkinje cell functional regions during reflexive visuomotor behaviours

    Laura D Knogler, Andreas M Kist, Ruben Portugues
    Purkinje cells of the cerebellum, a conserved vertebrate brain region important for sensorimotor integration, receive sensory and motor information from distinct input streams and are functionally clustered into modules reflecting the larval zebrafish's behavioral repertoire.
    1. Neuroscience

    Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    François Kroll, Joshua Donnelly ... Jason Rihel
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    1. Genetics and Genomics
    2. Neuroscience

    Sex-determining genes distinctly regulate courtship capability and target preference via sexually dimorphic neurons

    Kenichi Ishii, Margot Wohl ... Kenta Asahina
    Sex-specific characteristics of the fruit fly courtship behavior are not specified by a single binary switch, but as a combination of traits that are modularly specified by separable genetic switches.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat

    Mengyao Wang, Yu Qi ... Hongbing Han
    The Toll-like receptor 2-4 genetic modification goat improves effectively resistance against Staphylococcus aureus infection by enhancing autophagy level, and it provides a novel strategy for challenge of S. aureus-caused infections.
    1. Developmental Biology

    Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway

    Hyae Yon Kweon, Mi-Ni Lee ... Gholson J Lyon
    Mice doubly deficient for Naa10 and Naa12 display embryonic lethality, with both enzymes compensating for each other with amino-terminal acetylation of proteins in mouse development.

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