87 results found
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

    Kevin Achberger et al.
    A microphysiological system (retina-on-a-chip) shows the potential to promote drug development and provide new insights into the underlying pathology of retinal diseases.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Fish primary embryonic pluripotent cells assemble into retinal tissue mirroring in vivo early eye development

    Lucie Zilova et al.
    Fish-derived pluripotent cells instinctively form retinal tissue recapitulating key steps of early eye development.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Tissue Engineering: Building a better model of the retina

    Milica Radisic
    Researchers have combined organ-on-a-chip engineering with the benefits of organoids to make improved models of the human retina.
    Insight
    Available as:
    • HTML
    • PDF
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis

    Janani Gopalan et al.
    An anchored phosphatase-deacetylase complex participates in primary cilia development.
    1. Cell Biology

    Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model

    Magdalena Kasendra et al.
    Combining Organs-on-Chips technology with adult intestinal organoids provides an improved model of human duodenum and a new platform for preclinical drug assessment.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors

    Laura Crowley et al.
    Single-cell analyses identify distinct epithelial populations that are conserved between the adult mouse and human prostate, including populations with properties of multipotent progenitors in organoid formation and tissue reconstitution assays.
    1. Cell Biology
    2. Developmental Biology

    CytoCensus, mapping cell identity and division in tissues and organs using machine learning

    Martin Hailstone et al.
    Easy-to-use image analysis software enables single cell quantitation of cell types and division rates in complex 3D tissues including living Drosophila brains, mouse embryos and Zebrafish organoids.
    1. Developmental Biology

    A mammalian Wnt5a–Ror2–Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis

    Kuan Zhang et al.
    Regulation of cellular properties such as ligand secretion and migratory ability through changes in the cytoskeleton mediated by a Wnt5a–Ror2–Vangl2 axis is a major determinant of alveolar formation.
    1. Cancer Biology
    2. Cell Biology

    Secretion of protein disulphide isomerase AGR2 confers tumorigenic properties

    Delphine Fessart et al.
    Epithelial tumors secrete the ER-resident AGR2 in the extracellular matrix to function as a novel essential microenvironmental regulator of epithelial tissue architecture, which leads to tumorigenicity.
    1. Cancer Biology

    Acid-base transporters and pH dynamics in human breast carcinomas predict proliferative activity, metastasis, and survival

    Nicolai J Toft et al.
    Cellular acidity, capacity for net acid extrusion, and expression of acid-base transporters in human breast carcinomas independently predict variation in proliferative activity, lymph node metastasis, and patient survival.

Refine your results by:

Type
Research categories