241 results found
    1. Cell Biology
    2. Medicine

    eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin

    Takeshi Ninchoji et al.
    Vascular leakage from pathological vessels in retinopathy aggravates the disease, but endothelial junction stability and barrier integrity can be restored by blocking formation of nitric oxide.
    1. Developmental Biology

    Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease

    Daniyal J Jafree et al.
    Three-dimensional imaging was used to identify structural and quantitative features of developing lymphatics in the kidneys of mice, humans and in a genetic mouse model of polycystic kidney disease.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

    Kevin Achberger et al.
    A microphysiological system (retina-on-a-chip) shows the potential to promote drug development and provide new insights into the underlying pathology of retinal diseases.
    1. Immunology and Inflammation
    2. Neuroscience

    CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization

    Xiao Yang et al.
    Vascular degeneration of the choroid and RPE disorganization were associated with pharmacological macrophage ablation, indicating that insufficiency of macrophage function may be a mechanism underlying age- and AMD-associated pathology.
    1. Immunology and Inflammation
    2. Physics of Living Systems

    Label-free imaging of immune cell dynamics in the living retina using adaptive optics

    Aby Joseph et al.
    Immune cell motility and vascular response are imaged in vivo and label free in the CNS for the first time, using high-resolution phase-contrast adaptive optics retinal imaging.
    1. Immunology and Inflammation

    Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

    Ankit Jambusaria et al.
    Vascular endothelial cells in the brain, heart and lung exhibit tissue-specific heterogeneity and plasticity, expressing genes that were traditionally thought to be only expressed by the surrounding parenchymal tissue cells.
    1. Cell Biology
    2. Developmental Biology

    Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy

    Claudia Prahst et al.
    Improved 3D and 4D imaging of neurovascular processes across scales reveals new insights into eye disease mouse models and shows retinal vessels are significantly distorted using standard flat-mount confocal imaging.
    1. Developmental Biology

    Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII

    Man Chu et al.
    Analyses with genetically engineered mouse models in combination with biochemical approaches reveal a crucial role of the receptor tyrosine kinase Tie2 mediated signals in venogenesis via an Akt mediated regulation of COUP-TFII protein stabilization.
    1. Developmental Biology

    Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding

    Maria V Gelfand et al.
    Interactions between Neuropilin-1 and VEGFR2, rather than VEGF-Neuropilin-1 binding, underlie Neuropilin-1's critical function in VEGF-mediated vascular development.
    1. Developmental Biology

    Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development

    David AD Munro et al.
    Embryonic macrophages encourage early kidney development, interact with developing renal blood vessels, are enriched for mRNAs linked to vascular development, and promote endothelial cross-connections.

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