240 results found
    1. Developmental Biology
    2. Neuroscience

    Unbiased identification of novel transcription factors in striatal compartmentation and striosome maturation

    Maria-Daniela Cirnaru et al.
    RNAseq and ATACseq are utilized to identify transcription factors participating in striatal compartmentation into striosome and matrix, and roles for Stat1, Olig2, and Foxf2 are validated in vitro and in vivo.
    1. Genetics and Genomics
    2. Medicine

    SMA-miRs (miR-181a-5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples

    Emanuela Abiusi et al.
    The identification of SMA-miR supports the pathogenic role of skeletal muscle in spinal muscular atrophy and, integrated in the SMA-score, may help to improve the phenotypic prediction for patients.
    1. Genetics and Genomics
    2. Neuroscience

    Scaled, high fidelity electrophysiological, morphological, and transcriptomic cell characterization

    Brian R Lee et al.
    High-quality, multimodal, electrophysiological, morphological, and transcriptomic data collection from a single cell using a refined Patch-seq protocol.
    1. Developmental Biology
    2. Neuroscience

    Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa

    Liyun Zhang et al.
    Using a cross-species phenotypic drug discovery pipeline, compounds promoting rod photoreceptor survival in zebrafish and mouse models of retinitis pigmentosa were identified, evidence of additive effects of paired compounds and inhibition of PARP-dependent cell death suggest novel therapeutic strategies.
    1. Developmental Biology

    Development and genetics of red coloration in the zebrafish relative Danio albolineatus

    Delai Huang et al.
    In the zebrafish relative Danio albolineatus, red erythrophores share a common progenitor with yellow xanthophores and require Cyp2ae2 and Bdh1a for accumulation of red ketocarotenoid pigment.
    1. Developmental Biology

    Crosstalk between nitric oxide and retinoic acid pathways is essential for amphioxus pharynx development

    Filomena Caccavale et al.
    Previously undescribed morphogenetic and developmental mechanisms unravel that the cooperation of two ancient signaling pathways, nitric oxide and retinoic acid, is essential to build a chordate embryo.
    1. Microbiology and Infectious Disease

    Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma

    Elisa De Crignis et al.
    Human liver organoids provide a patient-derived platform to interrogate host and viral mechanisms of HBV replication, perform anti-HBV and toxicity drug screens, and investigate the molecular determinants of related tumorigenesis.
    1. Cell Biology
    2. Developmental Biology

    An in vitro stem cell model of human epiblast and yolk sac interaction

    Kirsty ML Mackinlay et al.
    Human yolk sac-like cells, which share characteristics with the post-implantation human hypoblast, can model the interaction between the epiblast and hypoblast that occurs during early human development.

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