240 results found
    1. Neuroscience

    Circuit organization of the excitatory sensorimotor loop through hand/forelimb S1 and M1

    Naoki Yamawaki et al.
    Cell-type-specific circuit analysis reveals a highly polysynaptic pattern of excitatory feedforward connections along the somatosensory-to-motor loop, from cuneate via VPL thalamus to S1 and M1 cortex and corticospinal neurons.
    1. Neuroscience

    Creating and controlling visual environments using BonVision

    Gonçalo Lopes et al.
    BonVision is an open-source software for real-time rendering and control of 2D and 3D visual environments that also enables easy replication of experiments.
    1. Cell Biology
    2. Developmental Biology

    CytoCensus, mapping cell identity and division in tissues and organs using machine learning

    Martin Hailstone et al.
    Easy-to-use image analysis software enables single cell quantitation of cell types and division rates in complex 3D tissues including living Drosophila brains, mouse embryos and Zebrafish organoids.
    1. Neuroscience

    An extended retinotopic map of mouse cortex

    Jun Zhuang et al.
    An expanded map of mouse cortex reveals the expansion of retinotopic organization into barrel and retrosplenial cortices.
    1. Immunology and Inflammation

    Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit

    Yasunobu Arima et al.
    A link between chronic stress and organ dysfunction is explained by the gateway reflex, in which brain micro-inflammation at specific vessels establishes a new neural pathway to induce fatal organ failure particularly in gastrointestine and heart.
    1. Neuroscience

    Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3

    Thomas O Auer et al.
    Disrupting synapse formation between the retina and the brain in zebrafish larvae-by eliminating the molecular motor Kif5A-triggers a compensatory increase in the branching of retinal axons aimed at restoring synapse number.
    1. Cell Biology

    Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model

    Magdalena Kasendra et al.
    Combining Organs-on-Chips technology with adult intestinal organoids provides an improved model of human duodenum and a new platform for preclinical drug assessment.
    1. Neuroscience

    A family of photoswitchable NMDA receptors

    Shai Berlin et al.
    Molecular engineering can generate light-sensitive NMDA receptors with specific subunit combinations.
    1. Cell Biology
    2. Medicine

    Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division

    Jin Rong Ow et al.
    Loss of hepatic Cdk1 leads to oxidative stress, increased fatty acids in blood, and hyperinsulinemia, which resulted in insulin resistance and hepatic steatosis, similar as in diabetes.
    1. Developmental Biology

    Neuronal octopamine signaling regulates mating-induced germline stem cell increase in female Drosophila melanogaster

    Yuto Yoshinari et al.
    Genetic analyses using the fruit fly illustrate how neuronal system couples germline stem cell increase to an external cue, which is mating, through stem cell niche signaling.

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