534 results found
    1. Neuroscience

    Slit2 as a β-catenin/Ctnnb1-dependent retrograde signal for presynaptic differentiation

    Haitao Wu et al.
    A novel retrograde signal is involved in nerve terminal differentiation at mouse neuromuscular junctions.
    1. Plant Biology

    A chloroplast retrograde signal, 3’-phosphoadenosine 5’-phosphate, acts as a secondary messenger in abscisic acid signaling in stomatal closure and germination

    Wannarat Pornsiriwong et al.
    Molecular signals from chloroplasts can synergistically interact with the plant hormone, abscisic acid (ABA), to regulate non-canonical signaling pathways mediating fundamental cellular processes including stomatal closure, seed dormancy and germination.
    1. Neuroscience

    Remodeling of lumbar motor circuitry remote to a thoracic spinal cord injury promotes locomotor recovery

    Ying Wang et al.
    Retrograde transport of NT-3 stimulated the reorganization of lumbar neural circuitry and synaptic connectivity remote to a thoracic SCI, along with improved behavioral recovery.
    1. Plant Biology

    Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors

    Alexey Shapiguzov et al.
    Signalling and metabolic interactions of the plant energy organelles, chloroplasts and mitochondria, depend on the nuclear regulatory protein RCD1.
    1. Neuroscience

    Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling

    Mengchen Ye et al.
    Multivesicular bodies deliver long-range retrograde nerve growth factor (NGF) signals and serve as essential signaling and sorting platforms in the cell soma, and multivesicular body (MVB) cargoes dictate their vesicular fate.
    1. Plant Biology

    A cis-carotene derived apocarotenoid regulates etioplast and chloroplast development

    Christopher I Cazzonelli et al.
    Carotenoids are not just required as core components for plastid biogenesis, they can be cleaved into an apocarotenoid signal that regulates etioplast and chloroplast development during extended periods of darkness.
    1. Neuroscience

    Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis in Xenopus

    Francois M Lambert et al.
    Molecular labeling, electrophysiology and calcium imaging have revealed a novel switching of neurotransmitter at the frog neuromuscular junction where motoneurons transiently release glutamate before acetylcholine at synapses on developing hindlimb muscles at the onset of metamorphosis.
    1. Neuroscience

    Stage-dependent remodeling of projections to motor cortex in ALS mouse model revealed by a new variant retrograde-AAV9

    Barbara Commisso et al.
    The projections from discrete areas to motor cortex increase over disease course in motoneuron disease model with selective spatial and temporal patterns.
    1. Cell Biology
    2. Genetics and Genomics

    The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response

    Karina Perlaza et al.
    A genetic screen in a unicellular photosynthetic organism uncovers the first essential signaling component in the chloroplast unfolded protein response that relays information from the chloroplast to the nuclear compartment.
    1. Neuroscience

    Semi-intact ex vivo approach to investigate spinal somatosensory circuits

    Junichi Hachisuka et al.
    A new spinal somatosensory preparation is described which enables fine control of sensory input and the ability to manipulate spinal interneurons while recording from spinal projection neurons.

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