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    1. Neuroscience

    Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA

    Míriam Javier-Torrent et al.
    EphA signaling plays dual opposite roles on axon dynamics in neurons, so it inhibits and promotes axon growth through ligand binding and receptor processing, respectively.
    1. Neuroscience

    Pathway-, layer- and cell-type-specific thalamic input to mouse barrel cortex

    B Semihcan Sermet et al.
    Two distinct thalamocortical pathways were found to provide differential excitatory synaptic input to distinct cell-types across layers of mouse primary somatosensory barrel cortex.
    1. Cell Biology
    2. Neuroscience

    Microtubules originate asymmetrically at the somatic golgi and are guided via Kinesin2 to maintain polarity within neurons

    Amrita Mukherjee et al.
    The somatic Golgi acts as an asymmetric MTOC within Drosophila neurons, and this, together with the action Kinesin-2, helps maintain minus-end-out microtubule polarity with proximal dendrites.
    1. Immunology and Inflammation
    2. Neuroscience

    A new genetic strategy for targeting microglia in development and disease

    Gabriel L McKinsey et al.
    P2ry12-CreER robustly and specifically labels microglia in fate-mapping and ribosomal profiling experiments, revealing new markers for myeloid subpopulations in the central nervous system.
    1. Cell Biology
    2. Developmental Biology

    Growth cone-localized microtubule organizing center establishes microtubule orientation in dendrites

    Xing Liang et al.
    In Caenorhabditis elegans, dendrites establish their unique microtubule polarity by localizing an organizing center behind the growing tip.
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

    Benjamin W Okaty et al.
    Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    An integrin/MFG-E8 shuttle loads HIV-1 viral-like particles onto follicular dendritic cells in mouse lymph node

    Chung Park, John H Kehrl
    Intravital imaging with HIV-1 viral-like particle in mouse model reveals a mechanism for HIV-1 uptake by subcapsular sinus macrophages that facilitates HIV-1 spreading tofollicular dendritic and B cells.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy

    Camilla Nehammer et al.
    A microRNA prevents the accumulation of toxic proteins by inducing autophagy.
    1. Neuroscience

    Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo

    Peter James Morgan et al.
    Short, theta-bursts of action potential firing decrease the global excitability of CA1 pyramidal neurons, providing an internal mechanism which could regulate their allocation to memory engrams.
    1. Neuroscience

    The hippocampus supports deliberation during value-based decisions

    Akram Bakkour et al.
    The deliberation involved in simple preference decisions, such as those between two familiar snacks, depends on the hippocampus.