19 results found
    1. Cell Biology
    2. Developmental Biology

    Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation

    Antonio Galeone et al.
    The cytoplasmic enzyme N-glycanase 1 plays an evolutionary conserved role in promoting the ERAD-mediated retrotranslocation of misfolded Dpp/BMP4 from the ER, thereby allowing BMP signaling in specific contexts.
    1. Cell Biology

    p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition

    Senthil K Radhakrishnan et al.
    The enzyme p97/VCP regulates the activity of the transcription factor Nrf1 to promote increased transcription of genes that encode proteasome subunits following inhibition of the proteasome.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1

    Brian G Peterson et al.
    The Hrd1-centric endoplasmic reticulum associated degradation system is regulated by interplay between the system's components.
    1. Cell Biology
    2. Genetics and Genomics

    A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency

    Dana M Talsness et al.
    An ion transporter is hyperglycosylated and 50% less functional in NGLY1-deficient cells, potentially explaining several symptoms of NGLY1 deficiency such as lack of sweat and tears.
    1. Biochemistry and Chemical Biology

    The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction

    Shun Koizumi et al.
    Peptidase activity of DDI2 is required to activate Nrf1 in order to enable proteasome recovery in response to proteasome inhibition.
    1. Cell Biology

    Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

    Gian-Luca McLelland et al.
    A crucial step during the mitophagy cascade involves the disassembly of connections between mitochondria and the endoplasmic reticulum via the retrotranslocation of Mfn2 tethering complexes by the Parkinson's disease genes PARKIN and PINK1, as well as the ATPase VCP/p97.
    1. Cell Biology

    USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

    Yanfen Liu et al.
    A deubiquitinase antagonizes the activity of an associated E3 ligase to prevent uncontrolled ubiquitination of a degradation machinery protein and thus maintain its functionality in protein quality control at the endoplasmic reticulum.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A polyomavirus peptide binds to the capsid VP1 pore and has potent antiviral activity against BK and JC polyomaviruses

    Joshua R Kane et al.
    A peptide derived from BK and JC polyomavirus protein VP2/3 inhibits viral infection by targeting a binding site in the pore of polyomavirus VP1 pentamers, enabling future VP1-targeted therapeutic strategies.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation

    Claudia C Schmidt et al.
    Doa10, a membrane-embedded ubiquitin ligase, facilitates the removal of membrane proteins from the endoplasmic reticulum and cooperates with the Cdc48 ATPase in this process.
    1. Cell Biology
    2. Developmental Biology

    Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1

    Nicolas J Lehrbach, Gary Ruvkun
    Post-translational processing of the SKN-1A/Nrf1 transcription factor regulates proteasome expression.

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