33 results found
    1. Chromosomes and Gene Expression

    A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics

    Nicole A Rapicavoli et al.
    A long non-coding RNA regulates the expression of genes that encode proteins involved in the inflammatory response.
    1. Developmental Biology

    p53 activity is selectively licensed in the Drosophila stem cell compartment

    Annika Wylie et al.
    Ancient features of the p53 regulatory network are coupled to the stem cell compartment in normal and pathologic contexts.
    1. Genetics and Genomics

    APOBEC3A deaminates transiently exposed single-strand DNA during LINE-1 retrotransposition

    Sandra R Richardson et al.
    Combining in vitro and in vivo assays demonstrates that the cytidine deaminase APOBEC3A can inhibit LINE-1 retrotransposition by deaminating transiently exposed single-strand DNA that arises during the process of LINE-1 integration.
    1. Stem Cells and Regenerative Medicine
    2. Genetics and Genomics

    A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics

    Irene Gallego Romero et al.
    A panel of chimpanzee induced pluripotent stem cells (iPSCs) will help realise the potential of iPSCs in primate studies, and in combination with genomic technologies, transform studies of comparative evolution.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome

    Yoong Wearn Lim et al.
    Global epigenetic perturbations and accumulation of RNA:DNA hybrids are two novel hallmarks of the lupus-like inflammatory disorder Aicardi-Goutières syndrome.
    1. Chromosomes and Gene Expression

    Genomic DNA transposition induced by human PGBD5

    Anton G Henssen et al.
    The human PGBD5 gene encodes an active DNA transposase.
    1. Developmental Biology

    The ‘de novo’ DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium

    Ellen N Elliott et al.
    The maintenance methyltransferase Dnmt1 and the de novo methyltransferase Dnmt3b cooperate to maintain DNA methylation and genomic stability in the adult intestinal epithelium.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Tracking interspecies transmission and long-term evolution of an ancient retrovirus using the genomes of modern mammals

    William E Diehl et al.
    Endogenous virus sequences in the genomes of modern mammals reveal the global spread of an ancient virus lineage, including frequent interspecies transmission, adaptation, and emergence spanning several million years of mammalian evolution
    1. Neuroscience

    Resolving rates of mutation in the brain using single-neuron genomics

    Gilad D Evrony et al.
    The reanalysis of data from a recent study that claimed retrotransposon mutations are ubiquitous in the human brain outlines a general framework for the design and analysis of single-cell genomics studies.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation

    Katia Ancelin et al.
    The maternally provided histone demethylase LSD1/KDM1A has an instrumental role at the beginning of life, shaping the histone methylation landscape and the transcriptional repertoire of the early mouse embryo.

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