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    1. Cell Biology
    2. Evolutionary Biology

    TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

    Michael Sulak et al.
    Elephants escaped enhanced cancer susceptibility by evolving more master tumor suppressor genes.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Natural depletion of histone H1 in sex cells causes DNA demethylation, heterochromatin decondensation and transposon activation

    Shengbo He et al.
    Transposon activation during male gametogenesis is caused by interactions between DNA demethylation and linker histone H1, developmental depletion of which promotes pollen fertility.
    1. Chromosomes and Gene Expression

    NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins

    Amy E Campbell et al.
    CRISPR/Cas9 engineered locus-specific proteomics leads to the identification of NuRD, CAF-1, and MBD3L2 as regulators of the early embryonic transcription factor DUX4.
    1. Stem Cells and Regenerative Medicine
    2. Genetics and Genomics

    Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells

    Marie MacLennan et al.
    Post-translational regulation of retrotransposons plays a key role in preventing retrotransposon mobilization in the epigenetically dynamic mouse germline.
    1. Neuroscience

    Resolving rates of mutation in the brain using single-neuron genomics

    Gilad D Evrony et al.
    The reanalysis of data from a recent study that claimed retrotransposon mutations are ubiquitous in the human brain outlines a general framework for the design and analysis of single-cell genomics studies.
    1. Chromosomes and Gene Expression

    Resolving the prevalence of somatic transposition in Drosophila

    Christoph D Treiber, Scott Waddell
    Current genome sequencing methods cannot reliably detect somatic transposition in Drosophila.
    1. Evolutionary Biology

    Splicing repression allows the gradual emergence of new Alu-exons in primate evolution

    Jan Attig et al.
    During evolutionary progression of Alu-exons, repressive U-tracts buffer sudden gains in 3' splice site strength and prevent inclusion of cryptic exons.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome

    Yoong Wearn Lim et al.
    Global epigenetic perturbations and accumulation of RNA:DNA hybrids are two novel hallmarks of the lupus-like inflammatory disorder Aicardi-Goutières syndrome.
    1. Chromosomes and Gene Expression

    A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics

    Nicole A Rapicavoli et al.
    A long non-coding RNA regulates the expression of genes that encode proteins involved in the inflammatory response.
    1. Biochemistry and Chemical Biology

    Group II intron inhibits conjugative relaxase expression in bacteria by mRNA targeting

    Guosheng Qu et al.
    Group II introns can target mRNA, causing inhibition of gene expression, as a potential driver for evolution to the spliceosome.