197 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

    Gernot Wolf, Alberto de Iaco ... Todd S Macfarlan
    Unbiased ChIP-seq screens and genetic knockouts of large Kruppel associated box zinc finger protein (KRAB-ZFP) clusters reveal that evolutionarily young KRAB-ZFPs play a redundant role in retrotransposon restriction in mice.
    1. Stem Cells and Regenerative Medicine
    2. Genetics and Genomics

    Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells

    Marie MacLennan, Marta García-Cañadas ... Ian R Adams
    Post-translational regulation of retrotransposons plays a key role in preventing retrotransposon mobilization in the epigenetically dynamic mouse germline.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci

    Claude Philippe, Dulce B Vargas-Landin ... Gaël Cristofari
    The expression of human L1 retrotransposons is highly locus-specific and variable between different cell types.
    1. Evolutionary Biology

    Adaptive evolution of an essential telomere protein restricts telomeric retrotransposons

    Bastien Saint-Leandre, Courtney Christopher, Mia T Levine
    Evolution strictly preserves telomere stability but rapidly diversifies telomere length regulation in Drosophila.
    1. Microbiology and Infectious Disease

    LINE-1 retrotransposons facilitate horizontal gene transfer into poxviruses

    M Julhasur Rahman, Sherry L Haller ... Stefan Rothenburg
    A new experimental system of horizontal gene transfer demonstrates that host retrotransposons facilitate the transfer of host genes into poxviruses.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Virophages and retrotransposons colonize the genomes of a heterotrophic flagellate

    Thomas Hackl, Sarah Duponchel ... Matthias G Fischer
    Mutualistic viruses called virophages are common genome inhabitants of a marine protist, where they may protect host populations from giant viruses.
    1. Cell Biology
    2. Neuroscience

    UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS

    Holly H Black, Jessica L Hanson ... Alexandra M Whiteley
    Exploring how UBQLN2 mutations cause ALS leads to the discovery of a pathway by which an ancient retroelement changes gene expression in human cells.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A spontaneous genetically induced epiallele at a retrotransposon shapes host genome function

    Tessa M Bertozzi, Nozomi Takahashi ... Anne C Ferguson-Smith
    A retrotransposon-derived recombination event in inbred mice gives rise to an epiallele and tissue-specific phenotypes.
    1. Cell Biology

    LINE-1 protein localization and functional dynamics during the cell cycle

    Paolo Mita, Aleksandra Wudzinska ... Jef D Boeke
    A combination of functional, biochemical and imaging studies show that LINE-1/L1 proteins and mRNA enter the nucleus through mitotic nuclear membrane breakdown, interact with components of the DNA replication fork and mediate retrotransposition during S phase.
    1. Genetics and Genomics

    Sequence features of retrotransposons allow for epigenetic variability

    Kevin R Costello, Amy Leung ... Dustin E Schones
    Variably methylated retrotransposons have an underlying sequence that allows them to escape KAP1-mediated silencing and recruit ZF-CxxC proteins.

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