58 results found
    1. Developmental Biology and Stem Cells
    2. Genomics and Evolutionary Biology

    Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells

    Marie MacLennan et al.
    Post-translational regulation of retrotransposons plays a key role in preventing retrotransposon mobilization in the epigenetically dynamic mouse germline.
    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci

    Claude Philippe et al.
    The expression of human L1 retrotransposons is highly locus-specific and variable between different cell types.
    1. Plant Biology

    Regulation of rice root development by a retrotransposon acting as a microRNA sponge

    Jungnam Cho, Jerzy Paszkowski
    Retrotransposon-derived messenger RNA plays a critical role in rice root development via sequestration of miR171, which suggests a novel trans-acting regulation by transposable elements.
    1. Cell Biology
    2. Genomics and Evolutionary Biology

    Retrotransposons: On the move

    Sandra L Martin
    The mechanisms by which a retrotransposon called LINE-1 duplicates itself and spreads through the human genome are becoming clearer.
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    1. Genomics and Evolutionary Biology
    2. Neuroscience

    Resolving rates of mutation in the brain using single-neuron genomics

    Gilad D Evrony et al.
    The reanalysis of data from a recent study that claimed retrotransposon mutations are ubiquitous in the human brain outlines a general framework for the design and analysis of single-cell genomics studies.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Dissection of affinity captured LINE-1 macromolecular complexes

    Martin S Taylor et al.
    The range of molecular forms adopted by L1 retrotransposons reflect a tapestry of lifecycle-permissive and -restrictive host-parasite interactions occurring within cells.
    1. Cell Biology
    2. Genomics and Evolutionary Biology

    LINE-1 protein localization and functional dynamics during the cell cycle

    Paolo Mita et al.
    A combination of functional, biochemical and imaging studies show that LINE-1/L1 proteins and mRNA enter the nucleus through mitotic nuclear membrane breakdown, interact with components of the DNA replication fork and mediate retrotransposition during S phase.
    1. Developmental Biology and Stem Cells
    2. Genes and Chromosomes

    Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation

    Katia Ancelin et al.
    The maternally provided histone demethylase LSD1/KDM1A has an instrumental role at the beginning of life, shaping the histone methylation landscape and the transcriptional repertoire of the early mouse embryo.
    1. Cancer Biology
    2. Genes and Chromosomes

    Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

    Simeon U Springer et al.
    The creation of a non-invasive assay for detecting urothelial cancer could have a profound impact on how we find and treat the disease.
    1. Ecology
    2. Genomics and Evolutionary Biology

    Transcriptome analysis illuminates the nature of the intracellular interaction in a vertebrate-algal symbiosis

    John A Burns et al.
    The endosymbiosis between an alga and the spotted salamander shows several parallels to invertebrate-algal symbioses as well as to pathogen associations in vertebrate animals.

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