Retrotransposon-derived messenger RNA plays a critical role in rice root development via sequestration of miR171, which suggests a novel trans-acting regulation by transposable elements.
Gilad D Evrony, Eunjung Lee ... Christopher A Walsh
The reanalysis of data from a recent study that claimed retrotransposon mutations are ubiquitous in the human brain outlines a general framework for the design and analysis of single-cell genomics studies.
Danielle J Owen, Elisa Aguilar-Martinez ... Andrew D Sharrocks
The transcriptional regulator ZMYM2 homes to distinct classes of retrotransposons bound by the TRIM28 and ChAHP chromatin complexes in human cells, which is broadly relevant in the transcriptional regulation field.
Yi-Ting Tsai, Nogayhan Seymen ... Mohammad M Karimi
Despite no observed correlation between retrotransposon (RTE) activity and chronological age, the expression of most RTE classes and families except SINEs correlated with biological age-associated gene signature scores.
The LINE-1 retrotransposon protein, ORF1p, forms a condensate on RNA that is essential for retrotransposition, and may explain cis-preference through a co-translational assembly mechanism.