18 results found
    1. Neuroscience

    The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO2

    Pierre-Louis Ruffault et al.
    The location of neurons responsible for increasing the breathing rate upon detecting elevated levels of CO2 in the blood has been pinpointed to the retrotrapezoid nucleus in the brainstem.
    1. Neuroscience

    Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe

    Virginia E Hawkins et al.
    CO2/H+-dependent purinergic signaling by astrocytes provides specialized control of vascular tone in a brainstem respiratory center in a manner that contributes to respiratory behavior.
    1. Neuroscience

    Vascular control of the CO2/H+-dependent drive to breathe

    Colin M Cleary et al.
    Understanding how loss of CO2/H+ vascular reactivity affects respiratory control may facilitate development of treatments for breathing problems in this population.
    1. Neuroscience

    Somatostatin-expressing parafacial neurons are CO2/H+ sensitive and regulate baseline breathing

    Colin M Cleary et al.
    Cellular and chemogenetic approaches identify a novel mode of chemotransduction involving regulation of basal breathing by CO2/H+-dependent disinhibition.
    1. Neuroscience

    Disordered breathing in a mouse model of Dravet syndrome

    Fu-Shan Kuo et al.
    Expression of a Dravet syndrome-associated mutation in inhibitory neurons disrupts activity of brainstem respiratory neurons and diminishes respiratory behavior in conjunction with seizures and premature death.
    1. Developmental Biology
    2. Neuroscience

    Loss of Atoh1 from neurons regulating hypoxic and hypercapnic chemoresponses causes neonatal respiratory failure in mice

    Meike E van der Heijden, Huda Y Zoghbi
    Atoh1 promotes the development of two different neural circuits involved in hypoxic and hypercapnic respiratory responses that together are essential for neonatal respiratory drive and survival.
    1. Neuroscience

    Atoh1-dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators in embryonic mice

    Srinivasan Tupal et al.
    The rhythmic patterns of activity that underlie breathing are generated and coordinated by distinct populations of neurons within the brainstem.
    1. Neuroscience

    C1 neurons are part of the circuitry that recruits active expiration in response to the activation of peripheral chemoreceptors

    Milene R Malheiros-Lima et al.
    An unbiased description reveals potential implications for understanding the developmental mechanisms that match respiratory supply and demand during hypoxia.
    1. Computational and Systems Biology
    2. Neuroscience

    CO2-evoked release of PGE2 modulates sighs and inspiration as demonstrated in brainstem organotypic culture

    David Forsberg et al.
    Novel brainstem organotypic cultures that generate rhythmic respiratory motor activity reveal the neural networks that control breathing and a new pathway in the hypercapnic response.
    1. Neuroscience

    Breathing: CO2 in the spotlight

    Luis R Hernandez-Miranda, Carmen Birchmeier
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