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Chemoreception: Keeping carbon dioxide in check
Alfredo J Garcia III, Jan-Marino Ramirez
The response of the brainstem to increased levels of carbon dioxide in the blood is coordinated with the response of the cardiovascular system.
Rhythmogenic Networks: The ins and outs of breathing
Jan-Marino Ramirez et al.
Two central pattern generators from the crab,
respond robustly and differentially to extreme extracellular pH
Jessica A Haley et al.
The rhythms generated by the stomatogastric and cardiac ganglia of the Jonah crab are surprisingly robust but differentially sensitive to acute changes in extracellular pH from pH 5.5 to 10.4.
Astrocytes release prostaglandin E2 to modify respiratory network activity
David Forsberg et al.
Astrocytes modulate neuronal networks during hypercapnia, introducing a novel gliotransmitter pathway where prostaglandin E2 regulates breathing.
protein-coupled receptors in dopamine neurons inhibit the sodium leak channel NALCN
Fabian Philippart, Zayd M Khaliq
The sodium leak NALCN channel functions as a core effector of GABA-B and D2 receptors that is used along with GIRK channels to regulate action potential firing in dopamine neurons.
Structural Biology and Molecular Biophysics
directly modulates connexin 26 by formation of carbamate bridges between subunits
Louise Meigh et al.
receptor and a mechanism for the CO
-mediated opening of gap junction hemichannels have been identified.
Interactions between respiratory oscillators in adult rats
Robert TR Huckstepp et al.
Active expiration in anesthetized rats is driven by the lateral parafacial region, but requires an additional form of excitation from another source.
A calcineurin-mediated scaling mechanism that controls a K
-leak channel to regulate morphogen and growth factor transcription
Chao Yi et al.
Calcineurin regulates an electrophysiological mechanism that activates the transcription of specific developmental genes in a heirarchical manner to scale fish appendages.
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