8,535 results found
    1. Neuroscience

    Functional heterogeneity within the rodent lateral orbitofrontal cortex dissociates outcome devaluation and reversal learning deficits

    Marios C Panayi, Simon Killcross
    The rodent orbitofrontal cortex makes functionally distinct contributions to flexible behavioural control, even within a single putative orbitofrontal subregion, which has important implications for establishing homology between rodent and primate orbitofrontal cortex.
    1. Neuroscience

    Recurrent network model for learning goal-directed sequences through reverse replay

    Tatsuya Haga, Tomoki Fukai
    The combination of short-term and long-term plasticity enables hippocampus to learn goal-directed paths through replay in a reversed order.
    1. Neuroscience

    Activity patterns of serotonin neurons underlying cognitive flexibility

    Sara Matias et al.
    Recordings from serotonin-producing neurons in the brain reveal that these neurons are highly activated by sudden changes in previously familiar environments, potentially explaining why serotonin is important for learning to adapt to such changes.
    1. Neuroscience

    Instructed knowledge shapes feedback-driven aversive learning in striatum and orbitofrontal cortex, but not the amygdala

    Lauren Y Atlas et al.
    While the striatum and orbitofrontal cortex learn about threats through verbal warnings, the amygdala learns only from direct experience, suggesting that the amygdala forms part of a specialized threat detection system.
    1. Stem Cells and Regenerative Medicine

    Live cell-lineage tracing and machine learning reveal patterns of organ regeneration

    Oriol Viader-Llargués et al.
    A combination of live cell tracking, cell-lineage tracing and machine learning shows that injured sensory organs repair accurately regardless of the extent of damage.
    1. Neuroscience

    Interneuron-specific gamma synchronization indexes cue uncertainty and prediction errors in lateral prefrontal and anterior cingulate cortex

    Kianoush Banaie Boroujeni et al.
    A fast spiking interneuron sub-type in medial and lateral prefrontal cortex fires and gamma-synchronizes prominently during adaptive learning of reward values when outcomes are uncertain and choice options have similar values.
    1. Neuroscience

    Distinct roles of striatal direct and indirect pathways in value-based decision making

    Shinae Kwak, Min Whan Jung
    The direct and indirect pathways of the dorsal striatum play indispensable roles in value-dependent action selection and value learning, respectively.
    1. Neuroscience

    Critical role for the mediodorsal thalamus in permitting rapid reward-guided updating in stochastic reward environments

    Subhojit Chakraborty et al.
    In monkeys, the integrity of the magnocellular subdivision of mediodorsal thalamus is important when using recent rewarded choices to promote persistence with a recently sampled choice during changing or uncertain reward guided-learning and decision-making tasks.
    1. Neuroscience

    The role of oxytocin in delay of gratification and flexibility in non-social decision making

    Georgia Eleni Kapetaniou et al.
    Oxytocin was found to significantly improve non-social decision making in a healthy sample, suggesting a domain-general function of the hormone, in contrast to its previously hypothesized social domain specificity.
    1. Neuroscience

    Dopamine neurons drive fear extinction learning by signaling the omission of expected aversive outcomes

    Ximena I Salinas-Hernández et al.
    Dopamine signaling is necessary for normal fear extinction learning.

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