6,695 results found
    1. Computational and Systems Biology

    Inferring characteristics of bacterial swimming in biofilm matrix from time-lapse confocal laser scanning microscopy

    Guillaume Ravel, Michel Bergmann ... Simon Labarthe
    A new mathematical method has been developed, implemented and validated for the analysis of time-lapse confocal laser scanning microscopy images to characterize the swimming behavior of bacterial swimmers moving in the exogenous matrix of pathogenic biofilms.
    1. Neuroscience

    Neural computations underlying inverse reinforcement learning in the human brain

    Sven Collette, Wolfgang M Pauli ... John O'Doherty
    The human brain is capable of implementing inverse reinforcement learning, where an observer infers the hidden reward structure of a decision problem solely through observing another individual take actions.
    1. Neuroscience

    Inferential eye movement control while following dynamic gaze

    Nicole Xiao Han, Miguel Patricio Eckstein
    When looking at another person shifting their gaze, humans use the gazer's head direction, velocity, and peripheral visual information to infer potential gaze goals and execute anticipatory eye movements.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanisms of nucleotide selection by telomerase

    Matthew A Schaich, Samantha L Sanford ... Bret D Freudenthal
    The roles of key telomerase active site residues were elucidated to determine how telomerase selects the correct from the incorrect nucleotide to maintain telomere integrity.
    1. Biochemistry and Chemical Biology

    Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition

    Clare Rollie, Stefanie Schneider ... Malcolm F White
    The acquisition of new foreign DNA by the prokaryotic adaptive immune system CRISPR-Cas is shown to depend on the fundamental sequence specificity of the Cas1 integrase.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Reverse evolution leads to genotypic incompatibility despite functional and active site convergence

    Miriam Kaltenbach, Colin J Jackson ... Nobuhiko Tokuriki
    Enzyme evolution is reversible on a structural and functional (phenotypic) level, but through a different mutational pathway that leads to genotypic incompatibility with the ancestor.
    1. Computational and Systems Biology
    2. Neuroscience

    Reverse engineering of metacognition

    Matthias Guggenmos
    A model framework and toolbox to quantify metacognitive biases and sources of metacognitive noise in animal and human confidence data.
    1. Computational and Systems Biology

    RNA polymerase errors cause splicing defects and can be regulated by differential expression of RNA polymerase subunits

    Lucas B Carey
    A single human cell makes 10-100 transcriptional errors per second; these errors affect splicing and may influence the evolution of coding sequences.
    1. Computational and Systems Biology
    2. Neuroscience

    Supercomputer framework for reverse engineering firing patterns of neuron populations to identify their synaptic inputs

    Matthieu K Chardon, Y Curtis Wang ... Charles J Heckman
    Estimating the organization of supraspinal input to motoneurons in humans is not currently possible, but a promising reverse engineering technique has been developed using large-scale supercomputing and computational neuroscience.
    1. Biochemistry and Chemical Biology

    Group II intron inhibits conjugative relaxase expression in bacteria by mRNA targeting

    Guosheng Qu, Carol Lyn Piazza ... Marlene Belfort
    Group II introns can target mRNA, causing inhibition of gene expression, as a potential driver for evolution to the spliceosome.

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