1,159 results found
    1. Biochemistry

    A reverse transcriptase ribozyme

    Biswajit Samanta, Gerald F Joyce
    An RNA enzyme is shown to function as a reverse transcriptase, an activity thought to be crucial for the transition from RNA to DNA genomes during the early history of life on Earth.
    1. Biophysics and Structural Biology

    Asymmetric conformational maturation of HIV-1 reverse transcriptase

    Xunhai Zheng et al.
    HIV-1 reverse transcriptase uses a metamorphic polymerase domain that minimizes its coding requirements but requires a complex maturation process.
    1. Biophysics and Structural Biology
    2. Genes and Chromosomes

    Single-molecule imaging of telomerase reverse transcriptase in human telomerase holoenzyme and minimal RNP complexes

    Robert Alexander Wu et al.
    New labeling approaches for single-molecule fluorescence microscopy detect the monomeric catalytic subunit of human telomerase within cellular holoenzyme and minimal active recombinant enzyme.
    1. Biochemistry

    Origin of life: Transitioning to DNA genomes in an RNA world

    Razvan Cojocaru, Peter J Unrau
    The unexpected ability of an RNA polymerase ribozyme to copy RNA into DNA has ramifications for understanding how DNA genomes evolved.
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  1. Point of View: Motivating participation in open science by examining researcher incentives

    Sarah E Ali-Khan et al.
    A survey of researchers at the Montreal Neurological Institute and Hospital provides insights into the challenges and opportunities involved in adopting an open science policy across an entire patient-oriented academic institution.
    1. Cell Biology

    mRNA Decay: How cells kill a "killer" messenger

    Cosmin Saveanu, Alain Jacquier
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