4,735 results found
    1. Developmental Biology

    T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number

    Uchenna Emechebe, Pavan Kumar P ... Anne M Moon
    The transcription and splicing factor T-box3 is present in primary cilia, regulates multiple aspects of limb development, and interacts with members of the protein complex required for the stability and processing of the Gli3 transcription factor.
    1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    Kinetics of the LOV domain of ZEITLUPE determine its circadian function in Arabidopsis

    Ashutosh Pudasaini, Jae Sung Shim ... Brian D Zoltowski
    In the plant circadian clock photoreceptor ZEITLUPE, evolutionarily selected residues distinguish photocycle kinetics and allosteric signal transduction pathways to permit proper circadian timing.
    1. Computational and Systems Biology
    2. Developmental Biology

    Elastic force restricts growth of the murine utricle

    Ksenia Gnedeva, Adrian Jacobo ... A J Hudspeth
    Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Mouse B2 SINE elements function as IFN-inducible enhancers

    Isabella Horton, Conor J Kelly ... Edward B Chuong
    An epigenomic analysis in mouse macrophages reveals that a highly abundant transposable element exhibits activity as an immune inducible regulatory element.
    1. Developmental Biology
    2. Evolutionary Biology

    An epithelial signalling centre in sharks supports homology of tooth morphogenesis in vertebrates

    Alexandre P Thiery, Ariane SI Standing ... Gareth J Fraser
    The development of diverse tooth shapes among vertebrates, from sharks to mammals, is a highly conserved process, utilising a similar dental signalling centre for more than 400 million years.
    1. Neuroscience

    Mechanical overstimulation causes acute injury and synapse loss followed by fast recovery in lateral-line neuromasts of larval zebrafish

    Melanie Holmgren, Michael E Ravicz ... Lavinia Sheets
    Mechanically induced injury of zebrafish lateral-line organs shares key features of damage observed in noise-exposed mammalian ears, such as inflammation and synapse loss, yet, unlike mammals, rapidly repairs following damage.
    1. Chromosomes and Gene Expression

    Nup98-dependent transcriptional memory is established independently of transcription

    Pau Pascual-Garcia, Shawn C Little, Maya Capelson
    Transcription and epigenetic memory of transcription are two co-occurring independent pathways, governed by different rate constants and unique parameters.
    1. Computational and Systems Biology
    2. Neuroscience

    Na+/K+ pump interacts with the h-current to control bursting activity in central pattern generator neurons of leeches

    Daniel Kueh, William H Barnett ... Ronald L Calabrese
    The dynamic current generated Na+/K+ pump interacts with the h-current to control the bursting activity of oscillator heart interneurons.
    1. Genetics and Genomics

    A population modification gene drive targeting both Saglin and Lipophorin impairs Plasmodium transmission in Anopheles mosquitoes

    Emily I Green, Etienne Jaouen ... Eric Marois
    Strong reduction in malaria transmission by genetically modified mosquitoes is achieved in the laboratory using a dual gene drive that simultaneously propagates an antiparasitic factor and a parasite-detrimental mosquito mutation.
    1. Cell Biology

    Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations

    Linda K Krasniewski, Papiya Chakraborty ... Myriam Gorospe
    Single-cell analysis of skeletal mouse reveals highly diverse macrophage subgroups associated with diverse functions and age-related changes.

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