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    1. Epidemiology and Global Health

    Mortality: The challenges of estimating biological age

    Alexey Moskalev
    A comparison of nine different approaches over a period of 20 years reveals the most promising indicators for biological age.
    Version of Record
    Insight
    1. Neuroscience

    Visual processing of informative multipoint correlations arises primarily in V2

    Yunguo Yu, Anita M Schmid, Jonathan D Victor
    Building on recent findings that central sensory processing allocates resources according to the informativeness of statistical features (Hermundstad et al., 2014), we identify visual area V2 as the site of the relevant computations for local image statistics, thus providing a common underpinning for diverse aspects of its neuronal selectivity.
    1. Neuroscience

    Contrary neuronal recalibration in different multisensory cortical areas

    Fu Zeng, Adam Zaidel, Aihua Chen
    Single-unit recordings from cortical neurons in behaving macaque monkeys expose differential aspects of multisensory plasticity across different multisensory areas during visual–vestibular recalibration.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs

    Jenny van Dongen, Gonneke Willemsen ... Michael C Neale
    Analysis of data from monozygotic twins reveals that DNA methylation level in human blood cells is reactive to cigarette smoking.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Universally high transcript error rates in bacteria

    Weiyi Li, Michael Lynch
    Fundamental details of the rate and molecular spectrum of transcript errors were revealed in four bacterial species, providing novel insights into transcriptional fidelity and RNA quality-control in prokaryotes.
    1. Neuroscience

    Inter-individual differences in human brain structure and morphology link to variation in demographics and behavior

    Alberto Llera, Thomas Wolfers ... Christian F Beckmann
    Multi-modal structural data fusion questions the specificity of fMRI-behavior associations by providing strong evidence relating human brain structure to a wide range of behavioral measures previously associated to functional connectivity.
    1. Neuroscience

    The role of conjunctive representations in prioritizing and selecting planned actions

    Atsushi Kikumoto, Ulrich Mayr, David Badre
    Time-resolved decoding of EEG reveals the nature of representations of upcoming actions and how the planned action is selected from working memory.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    circFL-seq reveals full-length circular RNAs with rolling circular reverse transcription and nanopore sequencing

    Zelin Liu, Changyu Tao ... Ence Yang
    Accurate identification and quantification of various circRNA isoforms.
    1. Neuroscience

    Hippocampal place cells construct reward related sequences through unexplored space

    H Freyja Ólafsdóttir, Caswell Barry ... Hugo J Spiers
    In anticipation of a reward, hippocampal place cells simulate desired journeys through areas that have been seen, but not explored.