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A computational method for predicting evolutionary pathways to antimicrobial resistance, accounting for how epistatic interactions determine trajectories, is described.

NPRL2 gene therapy induces robust antitumor immunity and overcome anti-PD1 resistance through augmenting antigen-presentation and cytotoxic T cells activation in KRAS/STK11 mutant NSCLC in humanized mouse model.

Computational and theoretical biomechanical analysis reveals how actomyosin filaments and axial muscles conjugate their activity to realize a fourfold elongation during C. elegans embryogenesis, 4 hr just before hatching.

The Self Returning Excluded Volume model is the first heuristic, stochastic chromatin model that reproduce single cell and ensemble based experiments bridging nucleosome and chromosome scales.

Genome sequencing of mice selected for longer limbs reveals that rapid selection response is due to both discrete loci and polygenic adaptation.

Immuno-affinity enrichment combined with liquid chromatography-mass spectrometry can be used to detect viral proteins to confirm the presence of SARS-CoV-2 in clinical samples.

An open-source tool for computational simulations of the human genome has been introduced, enabling the characterization of complex nuclear environments and the interpretation of experimental observations.

Detailed molecular characterization of a constitutively active bacterial NADPH oxidase (NOX) provides clues to the activation mechanism required to trigger electron transfer and reactive oxygen species (ROS) production in tightly regulated eukaryotic NOX.

Prevention and antivenom treatment could reduce snakebite deaths, which killed 1.2 million Indians from 2000-2019, about 70% of which occurred in eight states, and half during four rainy months.

Taxonomy of seizure dynamics (TSD) provides a rigorous method for classifying and quantifying seizures and a principled framework for understanding seizure initiation and propagation.