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    1. Developmental Biology

    Apelin signaling drives vascular endothelial cells toward a pro-angiogenic state

    Christian SM Helker et al.
    Apelin signaling promotes sprouting behavior of endothelial cells by modulating their metabolic state.
    1. Physics of Living Systems

    Deciphering the regulatory genome of Escherichia coli, one hundred promoters at a time

    William T Ireland et al.
    A combination of massively parallel reporter assays and mass spectrometry uncovers the regulation of previously unexplored promoters across the Escherichia coli genome.
    1. Medicine
    2. Neuroscience

    Parkinson’s Disease: Debunking an old theory

    Teresa Spix, Aryn Gittis
    Recording the neural activity of cells in the brain of patients with Parkinson's disease challenges long-standing assumptions about how this disease manifests at the cellular level.
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    1. Neuroscience

    Experience, circuit dynamics, and forebrain recruitment in larval zebrafish prey capture

    Claire S Oldfield et al.
    Experience strengthens hunting in larval zebrafish by recruiting the forebrain to increase the prey-evoked activity in visual areas and trigger motor activity and prey capture.
    1. Developmental Biology
    2. Neuroscience

    Learning steers the ontogeny of an efficient hunting sequence in zebrafish larvae

    Konstantinos Lagogiannis et al.
    Early hunting experience modifies the kinematics of hunting in larval zebrafish to increase the probability of successfully capturing live prey.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Caenorhabditis elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor

    Gabrielle E Giese et al.
    Metabolic activity of the methionine/S-adenosylmethionine cycle is sensed and transcriptionally regulated by a nuclear hormone receptor in Caenorhabditis elegans in order to maintain metabolic homeostasis in a tightly controlled regime.
    1. Neuroscience

    External location of touch is constructed post-hoc based on limb choice

    Femke Maij et al.
    Humans retrospectively localize touch after deciding on which limb it occurred, challenging the mainstream idea that tactile location in space is the basis for assigning touch to a body part.
    1. Neuroscience

    A dual role for Cav1.4 Ca2+ channels in the molecular and structural organization of the rod photoreceptor synapse

    J Wesley Maddox et al.
    Ca2+ influx through Cav1.4 channels is required for the structural, but not the molecular organization of the rod photoreceptor synapse.
    1. Neuroscience

    Purkinje cell neurotransmission patterns cerebellar basket cells into zonal modules defined by distinct pinceau sizes

    Joy Zhou et al.
    Targeted genetic silencing and reporter labeling reveal that Purkinje cell activity organizes cerebellar basket cells into zonal modules based on the sizes of their projections.
  1. Meta-Research: Questionable research practices may have little effect on replicability

    Rolf Ulrich, Jeff Miller
    Although questionable research practices inflate false positive rates, they have little effect on replicability because they also increase power.