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    1. Neuroscience

    Thalamocortical and corticothalamic pathways differentially contribute to goal-directed behaviors in the rat

    Fabien Alcaraz et al.
    Adaptive decision-making critically depends on antiparallel flows conveying distinct information within thalamocortical circuits, highlighting directionality of functional exchanges as a neural principle potentially at play in virtually any brain circuit with reciprocal projections.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The genetic factors of bilaterian evolution

    Peter Heger et al.
    Advanced orthology clustering of bilaterian and non-bilaterian sequences identifies 157 bilaterian-specific genes which are linked to key morphological features of this animal group.
    1. Epidemiology and Global Health

    FnCas9-based CRISPR diagnostic for rapid and accurate detection of major SARS-CoV-2 variants on a paper strip

    Manoj Kumar et al.
    A newly developed lateral flow assay can diagnose mutational signatures of major SARS CoV-2 variants in a rapid, inexpensive, and sequence-free manner.
    1. Neuroscience

    Accelerating with FlyBrainLab the discovery of the functional logic of the Drosophila brain in the connectomic and synaptomic era

    Aurel A Lazar et al.
    FlyBrainLab is an open-source computing platform that integrates 3D exploration and visualization of diverse Drosophila connectomic/synaptomic datasets with interactive exploration of the functional logic of modeled executable brain circuits.
    1. Neuroscience

    Separable neural signatures of confidence during perceptual decisions

    Tarryn Balsdon et al.
    Neural processes for perception and confidence can be separated thanks to computational electroencephalography, thus revealing a neural circuit specific to metacognition.
  1. Meta-Research: How significant are the public dimensions of faculty work in review, promotion and tenure documents?

    Juan P Alperin et al.
    An analysis of review, promotion and tenure documents from 129 US and Canadian universities suggests institutions could better fulfill their public missions by changing how they incentivize the public dimensions of faculty work.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Global divergence in critical income for adult and childhood survival: analyses of mortality using Michaelis–Menten

    Ryan J Hum et al.
    A mathematical model based on enzyme kinetics shows how the relationships between life expectancy, survival rates for children and adults, and national income change over time.
    1. Neuroscience

    Medical education and distrust modulate the response of insular-cingulate network and ventral striatum in pain diagnosis

    Giada Dirupo et al.
    Behavioral and neural data converge in showing that medical experience reduces reactions to others' pain and distrust toward the target affects the processing of his feedback.
  2. Meta-Research: Evaluating the impact of open access policies on research institutions

    Chun-Kai (Karl) Huang et al.
    A longitudinal study of open access levels at 1,207 research institutions worldwide reveals high performing institutions in Latin America, Africa and Asia.
    1. Neuroscience

    Vicarious reward unblocks associative learning about novel cues in male rats

    Sander van Gurp et al.
    Rats learn to interpret cues predicting rewards delivered to social partners as valuable, but only if social information exchange is possible.