1,597 results found
    1. Developmental Biology

    A minimally sufficient model for rib proximal-distal patterning based on genetic analysis and agent-based simulations

    Jennifer L Fogel et al.
    Specification and expansion during rib development is explained by Agent-Based Modeling while respecting the locality of decision-making that occurs as millions of cells coordinate their behavior to form and refine spatial pattern.
    1. Cell Biology
    2. Neuroscience

    Systematic functional analysis of rab GTPases reveals limits of neuronal robustness to environmental challenges in flies

    Friederike E Kohrs et al.
    The first complete null mutant collection of all rab GTPase genes in a multicellular organism uncovers neuronal development and function sensitive to environmental challenges in Drosophila.
    1. Cell Biology

    A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals

    Rosanna A Alegado et al.
    The development of colonies of cells in choanoflagellates, water-dwelling organisms that feed on bacteria, is triggered by the presence of very low concentrations of a lipid molecule produced by certain types of bacteria.
    1. Computational and Systems Biology
    2. Developmental Biology

    A human ESC-based screen identifies a role for the translated lncRNA LINC00261 in pancreatic endocrine differentiation

    Bjoern Gaertner et al.
    Ribosome profiling and loss-of-function during human ESC pancreatic differentiation reveal abundant lncRNA translation and an essential role for translated LINC00261 in beta cell differentiation, likely through a trans-regulatory, microprotein-independent mechanism.
    1. Cell Biology
    2. Neuroscience

    Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release

    Zhao Xuan et al.
    Clarinet, a novel C. elegans active zone protein with homology to vertebrate Piccolo and Rim, uses its different isoforms for diverse functions, including synaptic vesicle clustering, vesicle release and synaptogenesis.
    1. Cell Biology
    2. Plant Biology

    Two mechanisms regulate directional cell growth in Arabidopsis lateral roots

    Charlotte Kirchhelle et al.
    In lateral roots, cells employ a novel pathway to cell edges to control directional growth, which acts independently of the leading paradigm of oriented deposition of cellulose microfibrils at faces.
    1. Neuroscience

    Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans

    Byunghyuk Kim, Scott W Emmons
    The formation of neuronal connectivity of a C. elegans neuron pair is promoted by multiplexed interactions of neural cell adhesion proteins, which are evolutionarily conserved across animal taxa.
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    Large, long range tensile forces drive convergence during Xenopus blastopore closure and body axis elongation

    David R Shook et al.
    Blastopore closure in Xenopus is driven by two morphogenic mechanisms that have strongly context dependent effects on tissue movement and that generate tensile force across tissues: convergent extension, as expected, and, unexpectedly, convergent thickening.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

    Martin Steger et al.
    Discovery of a physiological LRRK2 substrate and a new mechanism of Rab regulation should aid Parkinson’s research and the understanding of Rab function.
    1. Cell Biology
    2. Cancer Biology

    BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function

    Xuetian Yue et al.
    Overexpression of BAG2—a novel mutant p53 binding protein—in tumors inhibits MDM2-mediated mutant p53 degradation, which leads to the accumulation of mutant p53 protein and promotes tumorigenesis.

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