800 results found
    1. Biochemistry
    2. Developmental Biology and Stem Cells

    Crk proteins transduce FGF signaling to promote lens fiber cell elongation

    Tamica N Collins et al.
    Crk proteins are critical mediators of FGF signaling to control cell shape changes.
    1. Cell Biology

    TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells

    Katerina Leonova et al.
    Type I interferon signaling protects cells from the loss of epigenetic integrity, since it is activated in cells in response to accumulation of transcripts originating from normally silenced heterochromatin, caused by small-molecule-mediated nucleosome unfolding.
    1. Cancer Biology

    Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers

    Xuehui Hong et al.
    A Methylation-Phosphorylation Switch Determines RioK1 Stability and Function in CRC and GC Progression.
    1. Neuroscience

    Multi-neuron intracellular recording in vivo via interacting autopatching robots

    Suhasa B Kodandaramaiah et al.
    A robot capable of automatically obtaining blind whole cell patch clamp recordings from multiple neurons simultaneously guides four interacting electrodes in a coordinated fashion, avoiding mechanical coupling in the brain.
    1. Cell Biology

    NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice

    James Anthony Loehr et al.
    Reative oxygen species modulate microtubules and diaphragm function.
    1. Neuroscience

    Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling

    Mengchen Ye et al.
    Multivesicular bodies deliver long-range retrograde nerve growth factor (NGF) signals and serve as essential signaling and sorting platforms in the cell soma, and multivesicular body (MVB) cargoes dictate their vesicular fate.
    1. Genes and Chromosomes
    2. Human Biology and Medicine

    Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

    Meritxell Espino Guarch et al.
    SLC7A8 a neutral amino acid transporter has a key role in the maintenance of hearing during aging and its absence causes early onset of hearing loss.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Multiple sources of slow activity fluctuations in a bacterial chemosensory network

    Remy Colin et al.
    Single-cell FRET measurements reveal large temporal activity fluctuations within this signaling pathway in Escherichia coli, caused by stochasticity of receptor methylation combined with allosteric interactions and slow rearrangements within receptor clusters.
    1. Developmental Biology and Stem Cells
    2. Genomics and Evolutionary Biology

    CRISPR/Cas9 and active genetics-based trans-species replacement of the endogenous Drosophila kni-L2 CRM reveals unexpected complexity

    Xiang-Ru Shannon Xu et al.
    Dissection of a cis-regulatory element (CRM) in its native chromosomal context using CRISPR/Cas9 editing and novel 'Active Genetics' reveals new features of CRM function and insights into how such regulatory elements change during evolution.
    1. Biochemistry

    RNA-dependent RNA targeting by CRISPR-Cas9

    Steven C Strutt et al.
    Divergent Cas9 enzymes direct site-specific single-stranded RNA cleavage, reducing infection by RNA phage in vivo and enabling programmable, PAM-independent repression of gene expression in bacteria.

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