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Microbiology and Infectious Disease
parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate
Natalie A Counihan et al.
Plasmodium parasites secrete RhopH2 from the rhoptry organelle into their host red blood cell to facilitate the uptake of essential nutrients required for parasite replication and survival.
Domestic chickens activate a piRNA defense against avian leukosis virus
Yu Huining Sun et al.
To protect the germ line genome, chickens acquire new small RNA-based immune defense in response to recently endogenized retroviruses by turning a truncated provirus into a weapon.
Genetic dissection of the Transcription Factor code controlling serial specification of muscle identities in
Laurence Dubois et al.
Lineage-specific regulatory loops involving evolutionarily conserved myogenic Transcription Factors control muscle identity specification in
alternative splicing during neuronal migration and axon guidance in the spinal cord
Janelle C Leggere et al.
Alternative splicing of the
gene, which is controlled by the NOVA RNA-binding proteins, is crucial during neuronal migration and axon guidance.
Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels
Hongkang Zhang et al.
Optogenetic tools enable sophisticated measurements of a voltage-gated sodium channel implicated in pain, as well as high-throughput screening of candidate channel blockers.
Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling
Scott J Neal et al.
CaMKI and neuroendocrine signaling integrate information about food status to regulate a developmental decision in
Genetics and Genomics
Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994
Aline Jelenkovic et al.
Genetic variance of adult human height shows a generally increasing trend across the birth-year cohorts but heritability estimates do not present any clear pattern of secular changes over a century.
Structural Biology and Molecular Biophysics
Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia
F Esra Demircioglu et al.
High resolution structures of the essential human AAA+ ATPase TorsinA and its disease mutant in complex with an activator reveal details of the interaction that will guide drug design and further functional characterization.
Computational and Systems Biology
Resolving coiled shapes reveals new reorientation behaviors in
Onno D Broekmans et al.
A conceptually simple algorithm can analyze previously uncharacterized 2D coiled postures of the nematode
and has uncovered new reorientation behaviors in large amplitude turns.
Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery
Rebekah Elizabeth Mahoney et al.
By regulating protein translation within the neuron, insulin signaling can control neuronal activity by altering the release of neurotransmitter molecules.
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