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    1. Cancer Biology

    TP53 drives invasion through expression of its Δ133p53β variant

    Gilles Gadea et al.
    Clinical analysis corroborated with experimental data demonstrate that Δ133p53β, a naturally occurring isoform of p53 protein, induces a pro-metastatic program and is a clinical indicator of metastasis, independently of TP53 mutation status.
    1. Human Biology and Medicine

    Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice

    Shunxing Rong et al.
    SREBP-2 directly regulates genes involved in cholesterol homeostasis and indirectly regulates fatty acid synthesis through the production of a ligand responsible for the activation of LXR and SREBP-1c.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

    Natalie A Counihan et al.
    Plasmodium parasites secrete RhopH2 from the rhoptry organelle into their host red blood cell to facilitate the uptake of essential nutrients required for parasite replication and survival.
    1. Developmental Biology
    2. Evolutionary Biology

    Domestic chickens activate a piRNA defense against avian leukosis virus

    Yu Huining Sun et al.
    To protect the germ line genome, chickens acquire new small RNA-based immune defense in response to recently endogenized retroviruses by turning a truncated provirus into a weapon.
    1. Developmental Biology
    2. Neuroscience

    NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord

    Janelle C Leggere et al.
    Alternative splicing of the Dcc gene, which is controlled by the NOVA RNA-binding proteins, is crucial during neuronal migration and axon guidance.
    1. Computational and Systems Biology
    2. Developmental Biology

    Unipolar distributions of junctional Myosin II identify cell stripe boundaries that drive cell intercalation throughout Drosophila axis extension

    Robert J Tetley et al.
    Analysing Myosin II unipolar planar polarisation with high spatial and temporal resolution during Drosophila axis extension reveals how tissue boundaries drive polarized cell intercalation while limiting cell mixing.
    1. Neuroscience

    Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels

    Hongkang Zhang et al.
    Optogenetic tools enable sophisticated measurements of a voltage-gated sodium channel implicated in pain, as well as high-throughput screening of candidate channel blockers.
    1. Developmental Biology
    2. Neuroscience

    Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling

    Scott J Neal et al.
    CaMKI and neuroendocrine signaling integrate information about food status to regulate a developmental decision in C. elegans.
    1. Genetics and Genomics

    Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

    Aline Jelenkovic et al.
    Genetic variance of adult human height shows a generally increasing trend across the birth-year cohorts but heritability estimates do not present any clear pattern of secular changes over a century.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia

    F Esra Demircioglu et al.
    High resolution structures of the essential human AAA+ ATPase TorsinA and its disease mutant in complex with an activator reveal details of the interaction that will guide drug design and further functional characterization.